Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood
Abstract Background Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one...
| Κύριοι συγγραφείς: | , , , , , , , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
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BMC
2023-10-01
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| Σειρά: | Clinical Epigenetics |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1186/s13148-023-01581-y |
| _version_ | 1827633807378874368 |
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| author | Phillip Collender Anne K. Bozack Stephanie Veazie Jamaji C. Nwanaji-Enwerem Lars Van Der Laan Katherine Kogut Corinne Riddell Brenda Eskenazi Nina Holland Julianna Deardorff Andres Cardenas |
| author_facet | Phillip Collender Anne K. Bozack Stephanie Veazie Jamaji C. Nwanaji-Enwerem Lars Van Der Laan Katherine Kogut Corinne Riddell Brenda Eskenazi Nina Holland Julianna Deardorff Andres Cardenas |
| author_sort | Phillip Collender |
| collection | DOAJ |
| description | Abstract Background Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one mechanism linking parental ACEs to child health. This study aimed to investigate epigenome-wide associations of maternal preconception ACEs with DNA methylation patterns of children. In the Center for the Health Assessment of Mothers and Children of Salinas study, cord blood DNA methylation was measured using the Illumina HumanMethylation450 BeadChip. Preconception ACEs, which occurred during the mothers’ childhoods, were collected using a standard ACE questionnaire including 10 ACE indicators. Maternal ACE exposures were defined in this study as (1) the total number of ACEs; (2) the total number of ACEs categorized as 0, 1–3, and > 4; and (3) individual ACEs. Associations of ACE exposures with differential methylated positions, regions, and CpG modules determined using weighted gene co-expression network analysis were evaluated adjusting for covariates. Results Data on maternal ACEs and cord blood DNA methylation were available for 196 mother/newborn pairs. One differential methylated position was associated with maternal experience of emotional abuse (cg05486260/FAM135B gene; q value < 0.05). Five differential methylated regions were significantly associated with the total number of ACEs, and 36 unique differential methylated regions were associated with individual ACEs (Šidák p value < 0.05). Fifteen CpG modules were significantly correlated with the total number of ACEs or individual ACEs, of which 8 remained significant in fully adjusted models (p value < 0.05). Significant modules were enriched for pathways related to neurological and immune development and function. Conclusions Maternal ACEs prior to conception were associated with cord blood DNA methylation of offspring at birth. Although there was limited overlap between differential methylated regions and CpGs in modules associated with ACE exposures, statistically significant regions and networks were related to genes involved in neurological and immune function. Findings may provide insights to pathways linking psychosocial stressors to health. Further research is needed to understand the relationship between changes in DNA methylation and child health. |
| first_indexed | 2024-03-09T15:04:40Z |
| format | Article |
| id | doaj.art-2b8a3771908b4ccc957ee20c28af83f7 |
| institution | Directory Open Access Journal |
| issn | 1868-7083 |
| language | English |
| last_indexed | 2024-03-09T15:04:40Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj.art-2b8a3771908b4ccc957ee20c28af83f72023-11-26T13:41:26ZengBMCClinical Epigenetics1868-70832023-10-0115112210.1186/s13148-023-01581-yMaternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord bloodPhillip Collender0Anne K. Bozack1Stephanie Veazie2Jamaji C. Nwanaji-Enwerem3Lars Van Der Laan4Katherine Kogut5Corinne Riddell6Brenda Eskenazi7Nina Holland8Julianna Deardorff9Andres Cardenas10Division of Environmental Health Sciences, University of CaliforniaDepartment of Epidemiology and Population Health, Stanford University School of MedicineDivision of Epidemiology, School of Public Health, University of CaliforniaGangarosa Department of Environmental Health, Rollins School of Public Health, Emory UniversityDepartment of Statistics, University of WashingtonDivision of Epidemiology, School of Public Health, University of CaliforniaDivision of Epidemiology, School of Public Health, University of CaliforniaCenter for Environmental Research of Community Health, CERCH, School of Public Health, University of CaliforniaDivision of Environmental Health Sciences, University of CaliforniaCenter for Environmental Research of Community Health, CERCH, School of Public Health, University of CaliforniaDepartment of Epidemiology and Population Health, Stanford University School of MedicineAbstract Background Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with mental and physical health of children. Epigenetic programming may be one mechanism linking parental ACEs to child health. This study aimed to investigate epigenome-wide associations of maternal preconception ACEs with DNA methylation patterns of children. In the Center for the Health Assessment of Mothers and Children of Salinas study, cord blood DNA methylation was measured using the Illumina HumanMethylation450 BeadChip. Preconception ACEs, which occurred during the mothers’ childhoods, were collected using a standard ACE questionnaire including 10 ACE indicators. Maternal ACE exposures were defined in this study as (1) the total number of ACEs; (2) the total number of ACEs categorized as 0, 1–3, and > 4; and (3) individual ACEs. Associations of ACE exposures with differential methylated positions, regions, and CpG modules determined using weighted gene co-expression network analysis were evaluated adjusting for covariates. Results Data on maternal ACEs and cord blood DNA methylation were available for 196 mother/newborn pairs. One differential methylated position was associated with maternal experience of emotional abuse (cg05486260/FAM135B gene; q value < 0.05). Five differential methylated regions were significantly associated with the total number of ACEs, and 36 unique differential methylated regions were associated with individual ACEs (Šidák p value < 0.05). Fifteen CpG modules were significantly correlated with the total number of ACEs or individual ACEs, of which 8 remained significant in fully adjusted models (p value < 0.05). Significant modules were enriched for pathways related to neurological and immune development and function. Conclusions Maternal ACEs prior to conception were associated with cord blood DNA methylation of offspring at birth. Although there was limited overlap between differential methylated regions and CpGs in modules associated with ACE exposures, statistically significant regions and networks were related to genes involved in neurological and immune function. Findings may provide insights to pathways linking psychosocial stressors to health. Further research is needed to understand the relationship between changes in DNA methylation and child health.https://doi.org/10.1186/s13148-023-01581-yACEsDNA methylationAdversityEpigenetic programming |
| spellingShingle | Phillip Collender Anne K. Bozack Stephanie Veazie Jamaji C. Nwanaji-Enwerem Lars Van Der Laan Katherine Kogut Corinne Riddell Brenda Eskenazi Nina Holland Julianna Deardorff Andres Cardenas Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood Clinical Epigenetics ACEs DNA methylation Adversity Epigenetic programming |
| title | Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood |
| title_full | Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood |
| title_fullStr | Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood |
| title_full_unstemmed | Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood |
| title_short | Maternal adverse childhood experiences (ACEs) and DNA methylation of newborns in cord blood |
| title_sort | maternal adverse childhood experiences aces and dna methylation of newborns in cord blood |
| topic | ACEs DNA methylation Adversity Epigenetic programming |
| url | https://doi.org/10.1186/s13148-023-01581-y |
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