Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics
Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addre...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Plant Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fpls.2020.00357/full |
| _version_ | 1819082752857735168 |
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| author | Kassiani Kytidou Marta Artola Marta Artola Herman S. Overkleeft Johannes M. F. G. Aerts |
| author_facet | Kassiani Kytidou Marta Artola Marta Artola Herman S. Overkleeft Johannes M. F. G. Aerts |
| author_sort | Kassiani Kytidou |
| collection | DOAJ |
| description | Plants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the central theme of the review. The therapeutic value of plant glycosidases is discussed as well as the present production in plant platforms of therapeutic human glycosidases used in enzyme replacement therapies. The increasing knowledge on glycosidases, including structure and catalytic mechanism, is described. The novel insights have allowed the design of functionalized highly specific suicide inhibitors of glycosidases. These so-called activity-based probes allow unprecedented visualization of glycosidases cross-species. Here, special attention is paid on the use of such probes in plant science that promote the discovery of novel enzymes and the identification of potential therapeutic inhibitors and chaperones. |
| first_indexed | 2024-12-21T20:21:40Z |
| format | Article |
| id | doaj.art-2b8a4a6c953c4f82a1f67d08e8a32021 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-21T20:21:40Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-2b8a4a6c953c4f82a1f67d08e8a320212022-12-21T18:51:29ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2020-04-011110.3389/fpls.2020.00357521948Plant Glycosides and Glycosidases: A Treasure-Trove for TherapeuticsKassiani Kytidou0Marta Artola1Marta Artola2Herman S. Overkleeft3Johannes M. F. G. Aerts4Department of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsDepartment of Medical Biochemistry, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsPlants contain numerous glycoconjugates that are metabolized by specific glucosyltransferases and hydrolyzed by specific glycosidases, some also catalyzing synthetic transglycosylation reactions. The documented value of plant-derived glycoconjugates to beneficially modulate metabolism is first addressed. Next, focus is given to glycosidases, the central theme of the review. The therapeutic value of plant glycosidases is discussed as well as the present production in plant platforms of therapeutic human glycosidases used in enzyme replacement therapies. The increasing knowledge on glycosidases, including structure and catalytic mechanism, is described. The novel insights have allowed the design of functionalized highly specific suicide inhibitors of glycosidases. These so-called activity-based probes allow unprecedented visualization of glycosidases cross-species. Here, special attention is paid on the use of such probes in plant science that promote the discovery of novel enzymes and the identification of potential therapeutic inhibitors and chaperones.https://www.frontiersin.org/article/10.3389/fpls.2020.00357/fullplant glycosidescarbohydrate processing enzymesglycosidasesglycosylationenzyme replacement therapy (ERT)plant production platforms |
| spellingShingle | Kassiani Kytidou Marta Artola Marta Artola Herman S. Overkleeft Johannes M. F. G. Aerts Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics Frontiers in Plant Science plant glycosides carbohydrate processing enzymes glycosidases glycosylation enzyme replacement therapy (ERT) plant production platforms |
| title | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| title_full | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| title_fullStr | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| title_full_unstemmed | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| title_short | Plant Glycosides and Glycosidases: A Treasure-Trove for Therapeutics |
| title_sort | plant glycosides and glycosidases a treasure trove for therapeutics |
| topic | plant glycosides carbohydrate processing enzymes glycosidases glycosylation enzyme replacement therapy (ERT) plant production platforms |
| url | https://www.frontiersin.org/article/10.3389/fpls.2020.00357/full |
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