Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population
Background: Diabetes mellitus type-2 (DMT2) could increase the risk of Alzheimers disease (AD) specifically related dementia, through several biological pathways, but the relationship between DM and the development of AD remains uncertain. Objectives: The aim of the present study was to explor...
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2011-08-01
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| Series: | Journal of the Dow University of Health Sciences |
| Subjects: | |
| Online Access: | https://jduhs.com/index.php/jduhs/article/view/1504 |
| _version_ | 1827940260899717120 |
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| author | Nelofer Sultana Zeenat Ayoob Masood A. Qureshi |
| author_facet | Nelofer Sultana Zeenat Ayoob Masood A. Qureshi |
| author_sort | Nelofer Sultana |
| collection | DOAJ |
| description | Background:
Diabetes mellitus type-2 (DMT2) could increase the risk of Alzheimers disease (AD) specifically related dementia, through several biological pathways, but the relationship between DM and the development of AD remains uncertain.
Objectives:
The aim of the present study was to explore the status of diabetes as one of the major risk factors of cognitive decline and dementia in AD and to compare the risk of developing AD among subjects with and without DM.
Methods:
The baseline examination was conducted from January 2008 to October 2010 on 611 subjects of both sexes who were above 50 years of age, to detect the prevalent cases of dementia. The Mini-Mental State Examination (MMSE) was done on all of these subjects. At each follow-up, random blood glucose levels were determined; all participants underwent a comprehensive clinical examination.
Results:
The study shows that risk of “dementia increases with age, duration of diabetes and relevant conditions e.g. obesity. The risk of “Dementia increases with duration of diabetes and the chi-square tests verify the claim. The calculated chi-square test statistics value was found to be 130.26 with degrees of freedom 9, corresponding p-value is (<0.005). It was also found that obese diabetics had higher risk of developing AD, as well as those having borderline diabetes were also at the higher risk.
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| first_indexed | 2024-03-13T09:07:36Z |
| format | Article |
| id | doaj.art-2b8a96ebaf214662991a85c3a6b1a25f |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T09:07:36Z |
| publishDate | 2011-08-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-2b8a96ebaf214662991a85c3a6b1a25f2023-05-28T03:11:33ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802011-08-0152Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani PopulationNelofer Sultana0Zeenat Ayoob1Masood A. Qureshi2Department of Physiology, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, PakistanProfessor of Physiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.Professor of Physiology, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan.Background: Diabetes mellitus type-2 (DMT2) could increase the risk of Alzheimers disease (AD) specifically related dementia, through several biological pathways, but the relationship between DM and the development of AD remains uncertain. Objectives: The aim of the present study was to explore the status of diabetes as one of the major risk factors of cognitive decline and dementia in AD and to compare the risk of developing AD among subjects with and without DM. Methods: The baseline examination was conducted from January 2008 to October 2010 on 611 subjects of both sexes who were above 50 years of age, to detect the prevalent cases of dementia. The Mini-Mental State Examination (MMSE) was done on all of these subjects. At each follow-up, random blood glucose levels were determined; all participants underwent a comprehensive clinical examination. Results: The study shows that risk of “dementia increases with age, duration of diabetes and relevant conditions e.g. obesity. The risk of “Dementia increases with duration of diabetes and the chi-square tests verify the claim. The calculated chi-square test statistics value was found to be 130.26 with degrees of freedom 9, corresponding p-value is (<0.005). It was also found that obese diabetics had higher risk of developing AD, as well as those having borderline diabetes were also at the higher risk. https://jduhs.com/index.php/jduhs/article/view/1504Diabetes mellitus type-2 (DMT2)alzheimer’s disease (AD)dementiacognitive declineobesity |
| spellingShingle | Nelofer Sultana Zeenat Ayoob Masood A. Qureshi Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population Journal of the Dow University of Health Sciences Diabetes mellitus type-2 (DMT2) alzheimer’s disease (AD) dementia cognitive decline obesity |
| title | Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population |
| title_full | Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population |
| title_fullStr | Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population |
| title_full_unstemmed | Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population |
| title_short | Diabetes Mellitus Type 2 as a Major Risk Factor of Developing Alzheimer's Disease in Pakistani Population |
| title_sort | diabetes mellitus type 2 as a major risk factor of developing alzheimer s disease in pakistani population |
| topic | Diabetes mellitus type-2 (DMT2) alzheimer’s disease (AD) dementia cognitive decline obesity |
| url | https://jduhs.com/index.php/jduhs/article/view/1504 |
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