Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.

Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes.

We report that Imetelstat, a telomerase inhibitor that binds to the RNA component of telomerase (hTR), can sensitize primary CLL lymphocytes to fludarabine in vitro. This effect was observed in lymphocytes from clinically resistant cases and with cytogenetic abnormalities associated with bad prognos...

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Bibliographic Details
Main Authors: May Shawi, Tsz Wai Chu, Veronica Martinez-Marignac, Y Yu, Sergei M Gryaznov, James B Johnston, Susan P Lees-Miller, Sarit E Assouline, Chantal Autexier, Raquel Aloyz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3726637?pdf=render

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