Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications
Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As major components of the TME, tumor-associated neutrophils (TANs) promote tumor progression and metastasis through communi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.938289/full |
| _version_ | 1811321137002446848 |
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| author | Man Yan Minying Zheng Rui Niu Xiaohui Yang Shifeng Tian Linlin Fan Yuwei Li Shiwu Zhang |
| author_facet | Man Yan Minying Zheng Rui Niu Xiaohui Yang Shifeng Tian Linlin Fan Yuwei Li Shiwu Zhang |
| author_sort | Man Yan |
| collection | DOAJ |
| description | Metastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As major components of the TME, tumor-associated neutrophils (TANs) promote tumor progression and metastasis through communication with multiple growth factors, chemokines, inflammatory factors, and other immune cells, which together establish an immunosuppressive TME. In this review, we describe the potential mechanisms by which TANs participate in tumor metastasis based on recent experimental evidence. We have focused on drugs in chemotherapeutic regimens that target TANs, thereby providing a promising future for cancer immunotherapy. |
| first_indexed | 2024-04-13T13:12:38Z |
| format | Article |
| id | doaj.art-2b8c07a642614f4db2d2a517bc4eafa7 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T13:12:38Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-2b8c07a642614f4db2d2a517bc4eafa72022-12-22T02:45:34ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-08-011010.3389/fcell.2022.938289938289Roles of tumor-associated neutrophils in tumor metastasis and its clinical applicationsMan Yan0Minying Zheng1Rui Niu2Xiaohui Yang3Shifeng Tian4Linlin Fan5Yuwei Li6Shiwu Zhang7Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Pathology, Tianjin Union Medical Center, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaNankai University School of Medicine, Nankai University, Tianjin, ChinaGraduate School, Tianjin Medical University, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Colorectal Surgery, Tianjin Union Medical Center, Tianjin, ChinaDepartment of Pathology, Tianjin Union Medical Center, Tianjin, ChinaMetastasis, a primary cause of death in patients with malignancies, is promoted by intrinsic changes in both tumor and non-malignant cells in the tumor microenvironment (TME). As major components of the TME, tumor-associated neutrophils (TANs) promote tumor progression and metastasis through communication with multiple growth factors, chemokines, inflammatory factors, and other immune cells, which together establish an immunosuppressive TME. In this review, we describe the potential mechanisms by which TANs participate in tumor metastasis based on recent experimental evidence. We have focused on drugs in chemotherapeutic regimens that target TANs, thereby providing a promising future for cancer immunotherapy.https://www.frontiersin.org/articles/10.3389/fcell.2022.938289/fullmetastasisneutrophilstumor-associated neutrophilstumor microenvironmentprognostic potentialsantitumor immunity |
| spellingShingle | Man Yan Minying Zheng Rui Niu Xiaohui Yang Shifeng Tian Linlin Fan Yuwei Li Shiwu Zhang Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications Frontiers in Cell and Developmental Biology metastasis neutrophils tumor-associated neutrophils tumor microenvironment prognostic potentials antitumor immunity |
| title | Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications |
| title_full | Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications |
| title_fullStr | Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications |
| title_full_unstemmed | Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications |
| title_short | Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications |
| title_sort | roles of tumor associated neutrophils in tumor metastasis and its clinical applications |
| topic | metastasis neutrophils tumor-associated neutrophils tumor microenvironment prognostic potentials antitumor immunity |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.938289/full |
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