Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?
Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospe...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-021-04831-3 |
| _version_ | 1818926784502038528 |
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| author | Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang |
| author_facet | Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang |
| author_sort | Zhimeng Wang |
| collection | DOAJ |
| description | Abstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. Results The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.(p < 0.05). In addition, better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.(p < 0.05). Conclusions Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss,maintain postoperative Hb levels,and with the advantage of accelerating recovery. |
| first_indexed | 2024-12-20T03:02:37Z |
| format | Article |
| id | doaj.art-2b8c178662cf41ef982457c5c891d0b7 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-20T03:02:37Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-2b8c178662cf41ef982457c5c891d0b72022-12-21T19:55:41ZengBMCBMC Musculoskeletal Disorders1471-24742021-11-0122111010.1186/s12891-021-04831-3Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy?Zhimeng Wang0Qiang Huang1Lu Liu2Yao Lu3Congming Zhang4Teng Ma5Zhong Li6Qian Wang7Hanzhong Xue8Kun Zhang9Department of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityDepartment of Orthopaedics and Trauma, Hong Hui Hospital, Xi’an Jiaotong UniversityAbstract Background Simultaneous bilateral distal tibial tubercle high tibial osteotomy (SBDTT-HTO) can result in increased blood loss. The aim of this study is to evaluate the actual hemostatic effect of different tranexamic acid (TXA) treatment regimen in SBDTT-HTO. Methods We conducted a retrospective case–control study including 54 patients who underwent SBDTT-HTO. The single-dose group (n = 18) received 1 g of intravenous TXA 15–30 min before surgery, the two-dose group (n = 18) received an additional 1 g of intravenous TXA 6 h after surgery, and the multiple-dose group (n = 18) received an additional 1 g intravenous TXA per-day until discharge. Blood loss, hemoglobin levels, occurrence of any adverse events,functional analysis, quality of life, and pain assessmentswere compared among the three groups. Results The total blood loss, hidden blood loss, drainage volumes, and haemoglobin level in the multiple-dose group all occupy a significant advantage.(p < 0.05). In addition, better quality of life were observed in patients belonging to the multiple-dose group then single-dose group.(p < 0.05). Conclusions Based on our results, for patients undergoing SBDTT-HTO, sequential intravenous TXA administration can effectively and safely reduce blood loss,maintain postoperative Hb levels,and with the advantage of accelerating recovery.https://doi.org/10.1186/s12891-021-04831-3Tranexamic acidBlood lossHigh tibial osteotomySimultaneous bilateral |
| spellingShingle | Zhimeng Wang Qiang Huang Lu Liu Yao Lu Congming Zhang Teng Ma Zhong Li Qian Wang Hanzhong Xue Kun Zhang Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? BMC Musculoskeletal Disorders Tranexamic acid Blood loss High tibial osteotomy Simultaneous bilateral |
| title | Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? |
| title_full | Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? |
| title_fullStr | Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? |
| title_full_unstemmed | Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? |
| title_short | Dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle-high tibial osteotomy? |
| title_sort | dose tranexamic acid reduce blood loss associated with simultaneous bilateral distal tibial tubercle high tibial osteotomy |
| topic | Tranexamic acid Blood loss High tibial osteotomy Simultaneous bilateral |
| url | https://doi.org/10.1186/s12891-021-04831-3 |
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