Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites
The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animal...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2015-05-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/67 |
| _version_ | 1826853448531836928 |
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| author | V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili |
| author_facet | V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili |
| author_sort | V. I. Dubrovina |
| collection | DOAJ |
| description | The article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animals. The metal-containing nanocomposites were used to improve the immunogenicity of this antigen preparation. The combined use of antigenic preparation S-2 with argentogalactomannan increases its immunogenic potency and conduces to the survival of experimental animals. Argentogalactomannan exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F2 Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines. |
| first_indexed | 2024-03-08T12:19:43Z |
| format | Article |
| id | doaj.art-2b8c601b1d844b2aabe1d4bb1fa3705f |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:26:09Z |
| publishDate | 2015-05-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-2b8c601b1d844b2aabe1d4bb1fa3705f2025-01-27T16:48:48ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962015-05-0103333767Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocompositesV. I. Dubrovina0T. A. Ivanova1S. V. Lukyanova2O. V. Yuryeva3S. A. Vityazeva4O. B. Kolesnikova5V. B. Nikolayev6S. V. Balakhonov7V. E. Takaishvili8Irkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorIrkutsk Antiplague Research Institute of Siberia and Far East of RospotrebnadzorThe article presents the research results of immunogenic potency of antigen preparation Bacillus anthracis Sterne 34F on the guinea pig model. It was found that a single inoculation of this preparation, before the contamination of virulent B. anthracis strain, protects 60-80 % of experimental animals. The metal-containing nanocomposites were used to improve the immunogenicity of this antigen preparation. The combined use of antigenic preparation S-2 with argentogalactomannan increases its immunogenic potency and conduces to the survival of experimental animals. Argentogalactomannan exhibits adjuvant properties enhanced the immunogenic features of the S-2 B. anthracis 34F2 Sterne that may indicate its availability as an adjuvant in the construction of chemical vaccines.https://www.actabiomedica.ru/jour/article/view/67bacillus anthracisantigennanocompositeimmunogenicity |
| spellingShingle | V. I. Dubrovina T. A. Ivanova S. V. Lukyanova O. V. Yuryeva S. A. Vityazeva O. B. Kolesnikova V. B. Nikolayev S. V. Balakhonov V. E. Takaishvili Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites Acta Biomedica Scientifica bacillus anthracis antigen nanocomposite immunogenicity |
| title | Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites |
| title_full | Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites |
| title_fullStr | Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites |
| title_full_unstemmed | Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites |
| title_short | Immunogenic potency of antigenic preparation Bacillus anthracis Sterne 34F<sub>2</sub> and its combination with metal-containing nanocomposites |
| title_sort | immunogenic potency of antigenic preparation bacillus anthracis sterne 34f sub 2 sub and its combination with metal containing nanocomposites |
| topic | bacillus anthracis antigen nanocomposite immunogenicity |
| url | https://www.actabiomedica.ru/jour/article/view/67 |
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