IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons
Control over the frequency and pattern of neuronal spike discharge depends on Ca2+-gated K+ channels that reduce cell excitability by hyperpolarizing the membrane potential. The Ca2+-dependent slow afterhyperpolarization (sAHP) is one of the most prominent inhibitory responses in the brain, with sAH...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2015-04-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715002958 |
| _version_ | 1819084106564108288 |
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| author | Brian King Arsalan P. Rizwan Hadhimulya Asmara Norman C. Heath Jordan D.T. Engbers Steven Dykstra Theodore M. Bartoletti Shahid Hameed Gerald W. Zamponi Ray W. Turner |
| author_facet | Brian King Arsalan P. Rizwan Hadhimulya Asmara Norman C. Heath Jordan D.T. Engbers Steven Dykstra Theodore M. Bartoletti Shahid Hameed Gerald W. Zamponi Ray W. Turner |
| author_sort | Brian King |
| collection | DOAJ |
| description | Control over the frequency and pattern of neuronal spike discharge depends on Ca2+-gated K+ channels that reduce cell excitability by hyperpolarizing the membrane potential. The Ca2+-dependent slow afterhyperpolarization (sAHP) is one of the most prominent inhibitory responses in the brain, with sAHP amplitude linked to a host of circuit and behavioral functions, yet the channel that underlies the sAHP has defied identification for decades. Here, we show that intermediate-conductance Ca2+-dependent K+ (IKCa) channels underlie the sAHP generated by trains of synaptic input or postsynaptic stimuli in CA1 hippocampal pyramidal cells. These findings are significant in providing a molecular identity for the sAHP of central neurons that will identify pharmacological tools capable of potentially modifying the several behavioral or disease states associated with the sAHP. |
| first_indexed | 2024-12-21T20:43:11Z |
| format | Article |
| id | doaj.art-2b8f5dd89d34414889368d339be70fe0 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-21T20:43:11Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-2b8f5dd89d34414889368d339be70fe02022-12-21T18:50:55ZengElsevierCell Reports2211-12472015-04-0111217518210.1016/j.celrep.2015.03.026IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal NeuronsBrian King0Arsalan P. Rizwan1Hadhimulya Asmara2Norman C. Heath3Jordan D.T. Engbers4Steven Dykstra5Theodore M. Bartoletti6Shahid Hameed7Gerald W. Zamponi8Ray W. Turner9Hotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaHotchkiss Brain Institute, University of Calgary, Calgary, AB T2N 4N1, CanadaControl over the frequency and pattern of neuronal spike discharge depends on Ca2+-gated K+ channels that reduce cell excitability by hyperpolarizing the membrane potential. The Ca2+-dependent slow afterhyperpolarization (sAHP) is one of the most prominent inhibitory responses in the brain, with sAHP amplitude linked to a host of circuit and behavioral functions, yet the channel that underlies the sAHP has defied identification for decades. Here, we show that intermediate-conductance Ca2+-dependent K+ (IKCa) channels underlie the sAHP generated by trains of synaptic input or postsynaptic stimuli in CA1 hippocampal pyramidal cells. These findings are significant in providing a molecular identity for the sAHP of central neurons that will identify pharmacological tools capable of potentially modifying the several behavioral or disease states associated with the sAHP.http://www.sciencedirect.com/science/article/pii/S2211124715002958 |
| spellingShingle | Brian King Arsalan P. Rizwan Hadhimulya Asmara Norman C. Heath Jordan D.T. Engbers Steven Dykstra Theodore M. Bartoletti Shahid Hameed Gerald W. Zamponi Ray W. Turner IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons Cell Reports |
| title | IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons |
| title_full | IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons |
| title_fullStr | IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons |
| title_full_unstemmed | IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons |
| title_short | IKCa Channels Are a Critical Determinant of the Slow AHP in CA1 Pyramidal Neurons |
| title_sort | ikca channels are a critical determinant of the slow ahp in ca1 pyramidal neurons |
| url | http://www.sciencedirect.com/science/article/pii/S2211124715002958 |
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