Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI
Abstract Background Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal thrombotic microangiopathy-based hematologic disease. Stroke has been reported as atypical neurological manifestations of TTP in some cases. Case presentation A 65-year-old male presented with typical acute ischemic st...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03489-9 |
| _version_ | 1797388251332345856 |
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| author | Ziyi Zhang Miao He |
| author_facet | Ziyi Zhang Miao He |
| author_sort | Ziyi Zhang |
| collection | DOAJ |
| description | Abstract Background Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal thrombotic microangiopathy-based hematologic disease. Stroke has been reported as atypical neurological manifestations of TTP in some cases. Case presentation A 65-year-old male presented with typical acute ischemic stroke symptoms including sudden-onset dysarthria, right-sided facial paralysis and hemiplegia. However, his CT and MRI scans were negative without showing any new ischemic lesions. He was diagnosed with TTP with severe thrombocytopenia, mild anemia, increased LDH, and low ADAMTS-13 activity. The symptoms and positive signs were rapidly resolved after administrating the plasma exchange therapy. Conclusion Clinicians should consider the possibility of TTP when a patient presents with acute stroke-like symptoms and thrombocytopenia, especially in an emergency room, either with or without new stroke lesions on the brain CT and MRI. |
| first_indexed | 2024-03-08T22:37:08Z |
| format | Article |
| id | doaj.art-2b8f6e2526f94842b2a4c268f60e8837 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-08T22:37:08Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-2b8f6e2526f94842b2a4c268f60e88372023-12-17T12:21:19ZengBMCBMC Neurology1471-23772023-12-012311410.1186/s12883-023-03489-9Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRIZiyi Zhang0Miao He1Department of Neurology, The Second Xiangya Hospital, Central South UniversityDepartment of Neurology, The Second Xiangya Hospital, Central South UniversityAbstract Background Thrombotic thrombocytopenic purpura (TTP) is a rare and fatal thrombotic microangiopathy-based hematologic disease. Stroke has been reported as atypical neurological manifestations of TTP in some cases. Case presentation A 65-year-old male presented with typical acute ischemic stroke symptoms including sudden-onset dysarthria, right-sided facial paralysis and hemiplegia. However, his CT and MRI scans were negative without showing any new ischemic lesions. He was diagnosed with TTP with severe thrombocytopenia, mild anemia, increased LDH, and low ADAMTS-13 activity. The symptoms and positive signs were rapidly resolved after administrating the plasma exchange therapy. Conclusion Clinicians should consider the possibility of TTP when a patient presents with acute stroke-like symptoms and thrombocytopenia, especially in an emergency room, either with or without new stroke lesions on the brain CT and MRI.https://doi.org/10.1186/s12883-023-03489-9Stroke mimicsThrombotic thrombocytopenic purpuraBrain MRI |
| spellingShingle | Ziyi Zhang Miao He Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI BMC Neurology Stroke mimics Thrombotic thrombocytopenic purpura Brain MRI |
| title | Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI |
| title_full | Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI |
| title_fullStr | Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI |
| title_full_unstemmed | Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI |
| title_short | Thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion-weighted MRI |
| title_sort | thrombotic thrombocytopenic purpura presenting as stroke mimics with normal diffusion weighted mri |
| topic | Stroke mimics Thrombotic thrombocytopenic purpura Brain MRI |
| url | https://doi.org/10.1186/s12883-023-03489-9 |
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