Effects of ambient PM2.5 on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway

Effects of ambient PM2.5 on development of psoriasiform inflammation through KRT17-dependent activation of AKT/mTOR/HIF-1α pathway

Exposure to fine particulate matter (PM2.5) has significant effects on human skin health, mainly disrupting skin homeostasis and accelerating aging. To date, the effects of PM2.5 on psoriasis (PSO) have not been elucidated. An ambient particulate matter exposed and well characterized imiquimod (IMQ)...

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Bibliographic Details
Main Authors: Xueliang Wang, Linpeng Niu, Aijuan Kang, Yaxian Pang, Yaling Zhang, Wenqing Wang, Yan Zhang, Xiaoyan Huang, Qingping Liu, Zihan Geng, Liyi He, Yujie Niu, Rong Zhang
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
KRT17
Psoriasis
AKT/mTOR/HIF-1α/signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132200848X

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