Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis
The human T cell lymphotropic virus type-1 (HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Dermatologic manifestations are com...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2019-05-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | http://acta.tums.ac.ir/index.php/acta/article/view/7222 |
| _version_ | 1818299158538223616 |
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| author | Reza Boostani Pouran Layegh Mohammad Javad Yazdanpanah Elham Vosoughi Azadeh Mohammadi Noseibe Joneidi Reyhaneh Bazargani Delaram Sayadpour Zanjani Saeed Ebrahimzadeh |
| author_facet | Reza Boostani Pouran Layegh Mohammad Javad Yazdanpanah Elham Vosoughi Azadeh Mohammadi Noseibe Joneidi Reyhaneh Bazargani Delaram Sayadpour Zanjani Saeed Ebrahimzadeh |
| author_sort | Reza Boostani |
| collection | DOAJ |
| description | The human T cell lymphotropic virus type-1 (HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad, Iran. Dermatological findings of 37 patients with HAM/TSP were investigated and compared with those of an HTLV-1 negative control group. A cutaneous biopsy was performed as needed, and the results were statistically analyzed. Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in the control group (64.9%) had at least one skin lesion or history of skin lesion before (P=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (P=0.000). Only xerosis was significantly associated with HAM/TSP. Skin manifestations were quite frequent in patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP. |
| first_indexed | 2024-12-13T04:46:47Z |
| format | Article |
| id | doaj.art-2b94cfe3387d4f05b490e85286fe6f1b |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-13T04:46:47Z |
| publishDate | 2019-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-2b94cfe3387d4f05b490e85286fe6f1b2022-12-21T23:59:07ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942019-05-011801837222Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic ParaparesisReza Boostani0Pouran Layegh1Mohammad Javad Yazdanpanah2Elham Vosoughi3Azadeh Mohammadi4Noseibe Joneidi5Reyhaneh Bazargani6Delaram Sayadpour Zanjani7Saeed Ebrahimzadeh8Department of Neurology, Quaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Research Center of Iranian Blood Transfusion Organization, Khorasan Razavi, Mashhad, Iran.Research Center of Iranian Blood Transfusion Organization, Khorasan Razavi, Mashhad, Iran.Department of Biostatistics and Epidemiology, Health Sciences Research Center, School of Health, Mashhad University of Medical Sciences Mashhad, Iran.The human T cell lymphotropic virus type-1 (HTLV-1) is associated with adult T cell leukemia/lymphoma (ATL) and other disorders, including a slowly progressive demyelinating paraparesis, known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Dermatologic manifestations are common in patients infected with HTLV-1 infection. In this study, we evaluated the dermatologic lesions associated with HAM/TSP patients in Mashhad, Iran. Dermatological findings of 37 patients with HAM/TSP were investigated and compared with those of an HTLV-1 negative control group. A cutaneous biopsy was performed as needed, and the results were statistically analyzed. Results of the present study showed that 34 cases with HAM/TSP (91.9%) and 24 cases in the control group (64.9%) had at least one skin lesion or history of skin lesion before (P=0.010). Xerosis was found in 22 persons (59.5%) in the case group and 4 persons in the control group (10.8%) (P=0.000). Only xerosis was significantly associated with HAM/TSP. Skin manifestations were quite frequent in patients with HAM/TSP. Xerosis was significantly associated with HAM/TSP.http://acta.tums.ac.ir/index.php/acta/article/view/7222HTLV-1HTLV-1 associated myelopathy (HAM)Tropical spastic paraparesis (TSP)Skin lesions |
| spellingShingle | Reza Boostani Pouran Layegh Mohammad Javad Yazdanpanah Elham Vosoughi Azadeh Mohammadi Noseibe Joneidi Reyhaneh Bazargani Delaram Sayadpour Zanjani Saeed Ebrahimzadeh Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Acta Medica Iranica HTLV-1 HTLV-1 associated myelopathy (HAM) Tropical spastic paraparesis (TSP) Skin lesions |
| title | Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_full | Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_fullStr | Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_full_unstemmed | Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_short | Dermatologic Manifestations in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis |
| title_sort | dermatologic manifestations in htlv 1 associated myelopathy tropical spastic paraparesis |
| topic | HTLV-1 HTLV-1 associated myelopathy (HAM) Tropical spastic paraparesis (TSP) Skin lesions |
| url | http://acta.tums.ac.ir/index.php/acta/article/view/7222 |
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