Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression
Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor prognosis are unresolved issues of PC. The concept of metabolic reprogramming is a hallmark of cancer cells. Increasing evi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1038650/full |
| _version_ | 1811298901525790720 |
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| author | Shi Dong Wancheng Li Xin Li Zhengfeng Wang Zhou Chen Huaqing Shi Ru He Chen Chen Wence Zhou |
| author_facet | Shi Dong Wancheng Li Xin Li Zhengfeng Wang Zhou Chen Huaqing Shi Ru He Chen Chen Wence Zhou |
| author_sort | Shi Dong |
| collection | DOAJ |
| description | Early and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor prognosis are unresolved issues of PC. The concept of metabolic reprogramming is a hallmark of cancer cells. Increasing evidence shows that PC cells alter metabolic processes such as glucose, amino acids, and lipids metabolism and require continuous nutrition for survival, proliferation, and invasion. Glucose metabolism, in particular, regulates the tumour microenvironment (TME). Furthermore, the link between glucose metabolism and TME also plays an important role in the targeted therapy, chemoresistance, radiotherapy ineffectiveness, and immunosuppression of PC. Altered metabolism with the TME has emerged as a key mechanism regulating PC progression. This review shed light on the relationship between TME, glucose metabolism, and various aspects of PC. The findings of this study provide a new direction in the development of PC therapy targeting the metabolism of cancer cells. |
| first_indexed | 2024-04-13T06:27:10Z |
| format | Article |
| id | doaj.art-2b98b353bf16445bacf0b7fa58b35503 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T06:27:10Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2b98b353bf16445bacf0b7fa58b355032022-12-22T02:58:21ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-12-011310.3389/fimmu.2022.10386501038650Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progressionShi Dong0Wancheng Li1Xin Li2Zhengfeng Wang3Zhou Chen4Huaqing Shi5Ru He6Chen Chen7Wence Zhou8The Second School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, The First Hospital of Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe Second School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaThe First School of Clinical Medicine, Lanzhou University, Lanzhou, ChinaDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, ChinaEarly and accurate diagnosis and treatment of pancreatic cancer (PC) remain challenging endeavors globally. Late diagnosis lag, high invasiveness, chemical resistance, and poor prognosis are unresolved issues of PC. The concept of metabolic reprogramming is a hallmark of cancer cells. Increasing evidence shows that PC cells alter metabolic processes such as glucose, amino acids, and lipids metabolism and require continuous nutrition for survival, proliferation, and invasion. Glucose metabolism, in particular, regulates the tumour microenvironment (TME). Furthermore, the link between glucose metabolism and TME also plays an important role in the targeted therapy, chemoresistance, radiotherapy ineffectiveness, and immunosuppression of PC. Altered metabolism with the TME has emerged as a key mechanism regulating PC progression. This review shed light on the relationship between TME, glucose metabolism, and various aspects of PC. The findings of this study provide a new direction in the development of PC therapy targeting the metabolism of cancer cells.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1038650/fullpancreatic cancertumour microenvironmentglucose metabolismtreatmentprognosis |
| spellingShingle | Shi Dong Wancheng Li Xin Li Zhengfeng Wang Zhou Chen Huaqing Shi Ru He Chen Chen Wence Zhou Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression Frontiers in Immunology pancreatic cancer tumour microenvironment glucose metabolism treatment prognosis |
| title | Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression |
| title_full | Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression |
| title_fullStr | Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression |
| title_full_unstemmed | Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression |
| title_short | Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression |
| title_sort | glucose metabolism and tumour microenvironment in pancreatic cancer a key link in cancer progression |
| topic | pancreatic cancer tumour microenvironment glucose metabolism treatment prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1038650/full |
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