Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study
ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep v...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2021-05-01
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279&tlng=en |
| _version_ | 1819243613664575488 |
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| author | Ufuk Turan Kursat Korkmaz Suleyman Ersoy Ahmet Yuksel Humeyra Celik Erhan Renan Ucaroglu Yusuf Velioglu Ayhan Cetinkaya Deniz Demir Umut Esen Kemalettin Erdem |
| author_facet | Ufuk Turan Kursat Korkmaz Suleyman Ersoy Ahmet Yuksel Humeyra Celik Erhan Renan Ucaroglu Yusuf Velioglu Ayhan Cetinkaya Deniz Demir Umut Esen Kemalettin Erdem |
| author_sort | Ufuk Turan Kursat Korkmaz |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT. |
| first_indexed | 2024-12-23T14:58:29Z |
| format | Article |
| id | doaj.art-2b99238d5ba5481cadb5e38971ff86fc |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-23T14:58:29Z |
| publishDate | 2021-05-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-2b99238d5ba5481cadb5e38971ff86fc2022-12-21T17:42:41ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602021-05-01139327928410.1590/1516-3180.2020.0457.r1.04022021Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control studyUfuk Turan Kursat Korkmazhttps://orcid.org/0000-0002-6107-2943Suleyman Ersoyhttps://orcid.org/0000-0003-0001-9329Ahmet Yukselhttps://orcid.org/0000-0003-0021-6509Humeyra Celikhttps://orcid.org/0000-0002-3394-2438Erhan Renan Ucarogluhttps://orcid.org/0000-0003-3655-1595Yusuf Veliogluhttps://orcid.org/0000-0003-4709-4705Ayhan Cetinkayahttps://orcid.org/0000-0002-8212-7149Deniz Demirhttps://orcid.org/0000-0003-2169-7647Umut Esenhttps://orcid.org/0000-0003-0916-6069Kemalettin Erdemhttps://orcid.org/0000-0002-5330-920XABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279&tlng=enVitamin DVenous thrombosis25-hydroxyvitamin D3 1-alpha-hydroxylaseDeep vein thrombosisDeep venous thromboses25(OH)D25-hydroxyvitamin D3Thrombosis, deep vein |
| spellingShingle | Ufuk Turan Kursat Korkmaz Suleyman Ersoy Ahmet Yuksel Humeyra Celik Erhan Renan Ucaroglu Yusuf Velioglu Ayhan Cetinkaya Deniz Demir Umut Esen Kemalettin Erdem Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study São Paulo Medical Journal Vitamin D Venous thrombosis 25-hydroxyvitamin D3 1-alpha-hydroxylase Deep vein thrombosis Deep venous thromboses 25(OH)D 25-hydroxyvitamin D3 Thrombosis, deep vein |
| title | Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_full | Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_fullStr | Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_full_unstemmed | Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_short | Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_sort | association between vitamin d levels and lower extremity deep vein thrombosis a case control study |
| topic | Vitamin D Venous thrombosis 25-hydroxyvitamin D3 1-alpha-hydroxylase Deep vein thrombosis Deep venous thromboses 25(OH)D 25-hydroxyvitamin D3 Thrombosis, deep vein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279&tlng=en |
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