Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis
Abstract Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce on...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04119-3 |
| _version_ | 1797557680161685504 |
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| author | Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai |
| author_facet | Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai |
| author_sort | Zhengchao Wang |
| collection | DOAJ |
| description | Abstract Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytokines. Recent studies have shown that PRP exhibits clinical benefits in patients with OA. However, high operational and equipment requirements greatly limit the application of PRP to OA treatment. Past studies have indicated that high-concentration PRP growth factors and cytokines may be applied as a commercial replacement for PRP. We reviewed the relevant articles to summarize the feasibility and mechanisms of PRP-based growth factors in OA. The available evidence suggests that transforming growth factor-α and β, platelet-derived growth factors, epidermal growth factor, insulin-like growth factor-1, and connective tissue growth factors might benefit OA, while vascular endothelial growth factor, tumor necrosis factor-α, angiopoietin-1, and stromal cell derived factor-1α might induce negative effects on OA. The effects of fibroblast growth factor, hepatocyte growth factor, platelet factor 4, and keratinocyte growth factor on OA remain uncertain. Thus, it can be concluded that not all cytokines released by PRP are beneficial, although the therapeutic action of PRP has a valuable potential to improve. |
| first_indexed | 2024-03-10T17:21:09Z |
| format | Article |
| id | doaj.art-2b9aaaaab57d4069b77a828b5506af01 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-10T17:21:09Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-2b9aaaaab57d4069b77a828b5506af012023-11-20T10:20:22ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-09-0118111210.1186/s13018-023-04119-3Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritisZhengchao Wang0Pengfei Zhu1Bokai Liao2Hongbo You3Yu Cai4Department of Orthopedics, Wuhan Fourth HospitalDepartment of Cardiovascular, Wuhan Fourth HospitalSchool of Chemistry and Chemical Engineering, Guangzhou UniversityDepartment of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University and TechnologyDepartment of Rehabilitation, Wuhan Fourth HospitalAbstract Osteoarthritis (OA) is defined as a degenerative joint disease that can affect all tissues of the joint, including the articular cartilage, subchondral bone, ligaments capsule, and synovial membrane. The conventional nonoperative treatments are ineffective for cartilage repair and induce only symptomatic relief. Platelet-rich plasma (PRP) is a platelet concentrate derived from autologous whole blood with a high concentration of platelets, which can exert anti-inflammatory and regenerative effects by releasing multiple growth factors and cytokines. Recent studies have shown that PRP exhibits clinical benefits in patients with OA. However, high operational and equipment requirements greatly limit the application of PRP to OA treatment. Past studies have indicated that high-concentration PRP growth factors and cytokines may be applied as a commercial replacement for PRP. We reviewed the relevant articles to summarize the feasibility and mechanisms of PRP-based growth factors in OA. The available evidence suggests that transforming growth factor-α and β, platelet-derived growth factors, epidermal growth factor, insulin-like growth factor-1, and connective tissue growth factors might benefit OA, while vascular endothelial growth factor, tumor necrosis factor-α, angiopoietin-1, and stromal cell derived factor-1α might induce negative effects on OA. The effects of fibroblast growth factor, hepatocyte growth factor, platelet factor 4, and keratinocyte growth factor on OA remain uncertain. Thus, it can be concluded that not all cytokines released by PRP are beneficial, although the therapeutic action of PRP has a valuable potential to improve.https://doi.org/10.1186/s13018-023-04119-3Platelet-rich plasmaOsteoarthritisCytokines |
| spellingShingle | Zhengchao Wang Pengfei Zhu Bokai Liao Hongbo You Yu Cai Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis Journal of Orthopaedic Surgery and Research Platelet-rich plasma Osteoarthritis Cytokines |
| title | Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis |
| title_full | Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis |
| title_fullStr | Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis |
| title_full_unstemmed | Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis |
| title_short | Effects and action mechanisms of individual cytokines contained in PRP on osteoarthritis |
| title_sort | effects and action mechanisms of individual cytokines contained in prp on osteoarthritis |
| topic | Platelet-rich plasma Osteoarthritis Cytokines |
| url | https://doi.org/10.1186/s13018-023-04119-3 |
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