Hepatitis C virus infection and risk of cancer: a population-based cohort study
Lars Haukali Omland1, Dora Körmendiné Farkas2, Peter Jepsen2,3, Niels Obel1, Lars Pedersen21Department of Infectious Diseases, Rigshospitalet, Denmark; 2Department of Clinical Epidemiology, 3Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hos...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2010-06-01
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| Series: | Clinical Epidemiology |
| Online Access: | http://www.dovepress.com/hepatitis-c-virus-infection-and-risk-of-cancer-a-population-based-coho-a4664 |
| _version_ | 1818139114453598208 |
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| author | Lars Haukali Omland Dora Körmendiné Farkas Peter Jepsen et al |
| author_facet | Lars Haukali Omland Dora Körmendiné Farkas Peter Jepsen et al |
| author_sort | Lars Haukali Omland |
| collection | DOAJ |
| description | Lars Haukali Omland1, Dora Körmendiné Farkas2, Peter Jepsen2,3, Niels Obel1, Lars Pedersen21Department of Infectious Diseases, Rigshospitalet, Denmark; 2Department of Clinical Epidemiology, 3Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DenmarkBackground: Hepatitis C virus (HCV) infection is associated with an increased risk of primary liver cancer; however, 5- and 10-year risk estimates are needed. The association of HCV with non-Hodgkin lymphoma (NHL) is uncertain and the association with other cancers is unknown.Method: We conducted a nationwide, population-based cohort study of 4,349 HCV-infected patients in Denmark, computing standardized incidence ratios (SIR) of cancer incidence in HCV infected patients compared with cancer incidence of the general population. We calculated 5-and 10-year risks of developing cancer, stratifying our analyses based on the presence of HIV coinfection and cirrhosis.Results: We recorded an increased risk of primary liver cancer (SIR: 76.63 [95% CI: 51.69–109.40]), NHL (SIR: 1.89 [95% CI: 0.39–5.52]), and several smoking- and alcohol-related cancers in HCV infected patients without HIV coinfection. HCV-infected patients without HIV coinfection had a 6.3% (95% CI: 4.6%–8.7%) risk of developing cancer and 2.0% (95% CI: 1.1%–3.8%) risk of developing primary liver cancer within 10 years.Conclusion: We confirmed the association of HCV infection with primary liver cancer and NHL. We also observed an association between HCV infection and alcohol- and smoking-related cancers.Keywords: hepatitis C virus, non-Hodgkin lymphoma, standardized incidence ratio, cancer |
| first_indexed | 2024-12-11T10:22:57Z |
| format | Article |
| id | doaj.art-2b9bd290a6bc4f779154d5795e952b81 |
| institution | Directory Open Access Journal |
| issn | 1179-1349 |
| language | English |
| last_indexed | 2024-12-11T10:22:57Z |
| publishDate | 2010-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Epidemiology |
| spelling | doaj.art-2b9bd290a6bc4f779154d5795e952b812022-12-22T01:11:17ZengDove Medical PressClinical Epidemiology1179-13492010-06-012010default179186Hepatitis C virus infection and risk of cancer: a population-based cohort studyLars Haukali OmlandDora Körmendiné FarkasPeter Jepsenet alLars Haukali Omland1, Dora Körmendiné Farkas2, Peter Jepsen2,3, Niels Obel1, Lars Pedersen21Department of Infectious Diseases, Rigshospitalet, Denmark; 2Department of Clinical Epidemiology, 3Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DenmarkBackground: Hepatitis C virus (HCV) infection is associated with an increased risk of primary liver cancer; however, 5- and 10-year risk estimates are needed. The association of HCV with non-Hodgkin lymphoma (NHL) is uncertain and the association with other cancers is unknown.Method: We conducted a nationwide, population-based cohort study of 4,349 HCV-infected patients in Denmark, computing standardized incidence ratios (SIR) of cancer incidence in HCV infected patients compared with cancer incidence of the general population. We calculated 5-and 10-year risks of developing cancer, stratifying our analyses based on the presence of HIV coinfection and cirrhosis.Results: We recorded an increased risk of primary liver cancer (SIR: 76.63 [95% CI: 51.69–109.40]), NHL (SIR: 1.89 [95% CI: 0.39–5.52]), and several smoking- and alcohol-related cancers in HCV infected patients without HIV coinfection. HCV-infected patients without HIV coinfection had a 6.3% (95% CI: 4.6%–8.7%) risk of developing cancer and 2.0% (95% CI: 1.1%–3.8%) risk of developing primary liver cancer within 10 years.Conclusion: We confirmed the association of HCV infection with primary liver cancer and NHL. We also observed an association between HCV infection and alcohol- and smoking-related cancers.Keywords: hepatitis C virus, non-Hodgkin lymphoma, standardized incidence ratio, cancerhttp://www.dovepress.com/hepatitis-c-virus-infection-and-risk-of-cancer-a-population-based-coho-a4664 |
| spellingShingle | Lars Haukali Omland Dora Körmendiné Farkas Peter Jepsen et al Hepatitis C virus infection and risk of cancer: a population-based cohort study Clinical Epidemiology |
| title | Hepatitis C virus infection and risk of cancer: a population-based cohort study |
| title_full | Hepatitis C virus infection and risk of cancer: a population-based cohort study |
| title_fullStr | Hepatitis C virus infection and risk of cancer: a population-based cohort study |
| title_full_unstemmed | Hepatitis C virus infection and risk of cancer: a population-based cohort study |
| title_short | Hepatitis C virus infection and risk of cancer: a population-based cohort study |
| title_sort | hepatitis c virus infection and risk of cancer a population based cohort study |
| url | http://www.dovepress.com/hepatitis-c-virus-infection-and-risk-of-cancer-a-population-based-coho-a4664 |
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