Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study
(1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)<sub>2</sub>D, and vitamin D levels with the risk of breast cancer in Malian...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-12-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/13/24/3664 |
| _version_ | 1827575104377192448 |
|---|---|
| author | Aboubacar D. T. Bissan Madani Ly Awo Emmanuela H. Amegonou Fatoumata M. Sidibe Bocary S. Koné Nènè Oumou K. Barry Madiné Tall Lassana G. Timbiné Bourèma Kouriba Pascal Reynier Zahra Ouzzif |
| author_facet | Aboubacar D. T. Bissan Madani Ly Awo Emmanuela H. Amegonou Fatoumata M. Sidibe Bocary S. Koné Nènè Oumou K. Barry Madiné Tall Lassana G. Timbiné Bourèma Kouriba Pascal Reynier Zahra Ouzzif |
| author_sort | Aboubacar D. T. Bissan |
| collection | DOAJ |
| description | (1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)<sub>2</sub>D, and vitamin D levels with the risk of breast cancer in Malian women. (2) Methods: We conducted a prospective case–control study from August 2021 to March 2022. Control subjects were matched to cases according to age (within 5 years). The patients’ clinical stage was determined by the oncologist according to the tumour–nodes–metastasis (TNM) classification system. (3) Results: We observed no differences in the mean 25(OH)D (<i>p</i> = 0.221) and 1,25(OH)<sub>2</sub>D (<i>p</i> = 0.285) between cases and controls. However, our findings indicate a more pronounced inverse association in the first level of plasma 25(OH)D, while the risk function decreases at higher levels. This observation takes strength with 1,25(OH)<sub>2</sub>D by a significant association between the first quartile and breast cancer as a risk factor (<i>p</i> = 0.03; OR = 71.84; CI: 1.36–3785.34). (4) Conclusions: These outcomes showed a possible association between 25(OH)D and 1,25(OH)<sub>2</sub>D in decreasing the risk of breast cancer. |
| first_indexed | 2024-03-08T20:51:32Z |
| format | Article |
| id | doaj.art-2b9ea98df73b431dbfd2211ff55f9eb2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-08T20:51:32Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2b9ea98df73b431dbfd2211ff55f9eb22023-12-22T14:03:16ZengMDPI AGDiagnostics2075-44182023-12-011324366410.3390/diagnostics13243664Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control StudyAboubacar D. T. Bissan0Madani Ly1Awo Emmanuela H. Amegonou2Fatoumata M. Sidibe3Bocary S. Koné4Nènè Oumou K. Barry5Madiné Tall6Lassana G. Timbiné7Bourèma Kouriba8Pascal Reynier9Zahra Ouzzif10Biochemistry, Metabolic and Molecular Unit, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat 10100, MoroccoUniversity Hospital of Luxembourg, Bamako BPE91094, MaliBiology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, MaliBiology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, MaliBiology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, MaliPharmaceutical Biochemistry Laboratory, Cheikh Anta Diop University of Dakar, Dakar BP 5005, SenegalCharles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, MaliCharles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, MaliCharles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, MaliDepartment of Biochemistry and Molecular Biology, University Hospital of Angers, 49933 Angers, FranceBiochemistry, Metabolic and Molecular Unit, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat 10100, Morocco(1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)<sub>2</sub>D, and vitamin D levels with the risk of breast cancer in Malian women. (2) Methods: We conducted a prospective case–control study from August 2021 to March 2022. Control subjects were matched to cases according to age (within 5 years). The patients’ clinical stage was determined by the oncologist according to the tumour–nodes–metastasis (TNM) classification system. (3) Results: We observed no differences in the mean 25(OH)D (<i>p</i> = 0.221) and 1,25(OH)<sub>2</sub>D (<i>p</i> = 0.285) between cases and controls. However, our findings indicate a more pronounced inverse association in the first level of plasma 25(OH)D, while the risk function decreases at higher levels. This observation takes strength with 1,25(OH)<sub>2</sub>D by a significant association between the first quartile and breast cancer as a risk factor (<i>p</i> = 0.03; OR = 71.84; CI: 1.36–3785.34). (4) Conclusions: These outcomes showed a possible association between 25(OH)D and 1,25(OH)<sub>2</sub>D in decreasing the risk of breast cancer.https://www.mdpi.com/2075-4418/13/24/3664breast cancer25-hydroxyvitamin D1,25-dihydroxyvitamin Dhypovitaminosis Dmetastasis |
| spellingShingle | Aboubacar D. T. Bissan Madani Ly Awo Emmanuela H. Amegonou Fatoumata M. Sidibe Bocary S. Koné Nènè Oumou K. Barry Madiné Tall Lassana G. Timbiné Bourèma Kouriba Pascal Reynier Zahra Ouzzif Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study Diagnostics breast cancer 25-hydroxyvitamin D 1,25-dihydroxyvitamin D hypovitaminosis D metastasis |
| title | Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study |
| title_full | Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study |
| title_fullStr | Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study |
| title_full_unstemmed | Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study |
| title_short | Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study |
| title_sort | plasma 25 hydroxyvitamin d and 1 25 dihydroxyvitamin d levels in breast cancer risk in mali a case control study |
| topic | breast cancer 25-hydroxyvitamin D 1,25-dihydroxyvitamin D hypovitaminosis D metastasis |
| url | https://www.mdpi.com/2075-4418/13/24/3664 |
| work_keys_str_mv | AT aboubacardtbissan plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT madanily plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT awoemmanuelahamegonou plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT fatoumatamsidibe plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT bocaryskone plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT neneoumoukbarry plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT madinetall plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT lassanagtimbine plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT bouremakouriba plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT pascalreynier plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy AT zahraouzzif plasma25hydroxyvitamindand125dihydroxyvitamindlevelsinbreastcancerriskinmaliacasecontrolstudy |