Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19
Pulmonary fibrosis is a well-recognized sequela associated with coronavirus disease 2019 (COVID-19), however the mechanism is yet to be clearly understood. The study was designed to evaluate the association of TNF-α, TGF- β1, amphiregulin, IL-2, and EGFR with pulmonary fibrosis after COVID-19 pneumo...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1876034122002106 |
| _version_ | 1828110257790910464 |
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| author | Daniel Maranatha Helmia Hasan Arief Bakhtiar Anita Widyoningroem Aryati |
| author_facet | Daniel Maranatha Helmia Hasan Arief Bakhtiar Anita Widyoningroem Aryati |
| author_sort | Daniel Maranatha |
| collection | DOAJ |
| description | Pulmonary fibrosis is a well-recognized sequela associated with coronavirus disease 2019 (COVID-19), however the mechanism is yet to be clearly understood. The study was designed to evaluate the association of TNF-α, TGF- β1, amphiregulin, IL-2, and EGFR with pulmonary fibrosis after COVID-19 pneumonia. Non-severe, severe, and critical COVID-19 pneumonia patients were included in this study after the patients agreed and gave written informed consent. Blood samples were analyzed with the ELISA method for cytokine examination. The non-contrast chest CT scan was performed after patients were discharged from hospital. Seventy-nine patients with a mean age of 54 years (57 % men, 43 % women) were fully evaluated. Pulmonary fibrosis was found in 74 patients (93.7 %). Serum levels of TGF-β1 60.55 pg/mL (11.42–2001.16), TNF-α 13.31 pg/mL (3.54–200.32), EGFR 14.9 pg/mL(6.4–53.6), IL-2 12.41 pg/mL(11–14.13), amphiregulin 156.5 pg/mL (21.7–1234). Serum levels of TNF-α increase according to the severity of clinical classification. A significant association between serum levels of TGF-β1, TNF- α, and pulmonary fibrosis with rs-0.247, p = 0.027; rs 0.259, p = 0.046 was found. According to this study, TNF-α and TGF-β1 potentially participate in the process of pulmonary fibrosis in COVID-19. |
| first_indexed | 2024-04-11T11:17:16Z |
| format | Article |
| id | doaj.art-2b9feeef4fef4229958b4d6b35c9c537 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-11T11:17:16Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-2b9feeef4fef4229958b4d6b35c9c5372022-12-22T04:27:11ZengElsevierJournal of Infection and Public Health1876-03412022-10-01151010721075Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19Daniel Maranatha0Helmia Hasan1Arief Bakhtiar2Anita Widyoningroem3 Aryati4Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Hospital, Indonesia; Correspondence to: Department of Pulmonology and Respiratory Medicine Department, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo Academic Hospital, Jl. Prof. Dr. Moestopo 6–8, Surabaya, 60182, Indonesia.Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Hospital, IndonesiaDepartment of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Hospital, IndonesiaDepartment of Radiology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Hospital, IndonesiaDepartment of Clinical Pathology, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo Academic Hospital, IndonesiaPulmonary fibrosis is a well-recognized sequela associated with coronavirus disease 2019 (COVID-19), however the mechanism is yet to be clearly understood. The study was designed to evaluate the association of TNF-α, TGF- β1, amphiregulin, IL-2, and EGFR with pulmonary fibrosis after COVID-19 pneumonia. Non-severe, severe, and critical COVID-19 pneumonia patients were included in this study after the patients agreed and gave written informed consent. Blood samples were analyzed with the ELISA method for cytokine examination. The non-contrast chest CT scan was performed after patients were discharged from hospital. Seventy-nine patients with a mean age of 54 years (57 % men, 43 % women) were fully evaluated. Pulmonary fibrosis was found in 74 patients (93.7 %). Serum levels of TGF-β1 60.55 pg/mL (11.42–2001.16), TNF-α 13.31 pg/mL (3.54–200.32), EGFR 14.9 pg/mL(6.4–53.6), IL-2 12.41 pg/mL(11–14.13), amphiregulin 156.5 pg/mL (21.7–1234). Serum levels of TNF-α increase according to the severity of clinical classification. A significant association between serum levels of TGF-β1, TNF- α, and pulmonary fibrosis with rs-0.247, p = 0.027; rs 0.259, p = 0.046 was found. According to this study, TNF-α and TGF-β1 potentially participate in the process of pulmonary fibrosis in COVID-19.http://www.sciencedirect.com/science/article/pii/S1876034122002106COVID-19TNF-αTGF-β1Pulmonary fibrosis |
| spellingShingle | Daniel Maranatha Helmia Hasan Arief Bakhtiar Anita Widyoningroem Aryati Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 Journal of Infection and Public Health COVID-19 TNF-α TGF-β1 Pulmonary fibrosis |
| title | Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 |
| title_full | Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 |
| title_fullStr | Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 |
| title_full_unstemmed | Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 |
| title_short | Association of TNF-α, TGF-β1, amphiregulin, IL-2, and EGFR WITH pulmonary fibrosis in COVID-19 |
| title_sort | association of tnf α tgf β1 amphiregulin il 2 and egfr with pulmonary fibrosis in covid 19 |
| topic | COVID-19 TNF-α TGF-β1 Pulmonary fibrosis |
| url | http://www.sciencedirect.com/science/article/pii/S1876034122002106 |
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