Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

Thrombin-induced, TNFR-dependent miR-181c downregulation promotes MLL1 and NF-κB target gene expression in human microglia

Abstract Background Controlling thrombin-driven microglial activation may serve as a therapeutic target for intracerebral hemorrhage (ICH). Here, we investigated microRNA (miRNA)-based regulation of thrombin-driven microglial activation using an in vitro thrombin toxicity model applied to primary hu...

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Bibliographic Details
Main Authors: Min Yin, Zhiying Chen, Yetong Ouyang, Huiyan Zhang, Zhigang Wan, Han Wang, Wei Wu, Xiaoping Yin
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Journal of Neuroinflammation
Subjects:
Intracerebral hemorrhage
ICH
Thrombin
Microglia
MicroRNA
Online Access:http://link.springer.com/article/10.1186/s12974-017-0887-5

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http://link.springer.com/article/10.1186/s12974-017-0887-5

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