Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet
Metabolically beneficial effects of decursin and decursinol angelate have been reported. However, it is unclear whether Angelica gigas Nakai extract (AGNE), which is rich in decursin and decursinol angelate, can alleviate high-fat diet (HFD)-mediated non-alcoholic fatty liver disease and dyslipidemi...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464617300804 |
| _version_ | 1818723644266774528 |
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| author | Ui-Jin Bae Mi-Ra Oh Tae-Sung Jung Soo-Wan Chae Byung-Hyun Park |
| author_facet | Ui-Jin Bae Mi-Ra Oh Tae-Sung Jung Soo-Wan Chae Byung-Hyun Park |
| author_sort | Ui-Jin Bae |
| collection | DOAJ |
| description | Metabolically beneficial effects of decursin and decursinol angelate have been reported. However, it is unclear whether Angelica gigas Nakai extract (AGNE), which is rich in decursin and decursinol angelate, can alleviate high-fat diet (HFD)-mediated non-alcoholic fatty liver disease and dyslipidemia. In this study, c57BL6/J mice were fed a HFD, or HFD with various doses of AGNE for 16 weeks. Supplementation with AGNE attenuated glucose and insulin intolerance, hepatic steatosis and inflammation, and hypertriglyceridemia induced by the HFD. AGNE significantly suppressed hepatic de novo lipogenesis through activation of adenosine monophosphate-activated protein kinase (AMPK). HepG2 cells treated with free fatty acid mixture (oleate:palmitate = 2:1) displayed increases of de novo lipogenesis and consequent lipid droplet formation. Addition of decursin or decursinol angelate increased Sirt1 expression, which suppressed lipid accumulation in HepG2 cells. These results indicate that the metabolic effects of AGNE may be related to the induction of Sirt1 and consequent activation of AMPK. |
| first_indexed | 2024-12-17T21:13:48Z |
| format | Article |
| id | doaj.art-2ba06d2f125c42878caad7c5e9f01598 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T21:13:48Z |
| publishDate | 2017-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-2ba06d2f125c42878caad7c5e9f015982022-12-21T21:32:23ZengElsevierJournal of Functional Foods1756-46462017-04-0131208216Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat dietUi-Jin Bae0Mi-Ra Oh1Tae-Sung Jung2Soo-Wan Chae3Byung-Hyun Park4Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of KoreaClinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of KoreaWellbeingproducts Co., Ltd, Anyang, Gyeonggi 14607, Republic of KoreaClinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Republic of Korea; Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea; Corresponding authors at: Department of Biochemistry, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 54896, Republic of Korea (B.-H. Park). Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 54896, Republic of Korea (S.-W. Chae).Department of Biochemistry, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Republic of Korea; Corresponding authors at: Department of Biochemistry, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 54896, Republic of Korea (B.-H. Park). Department of Pharmacology, Chonbuk National University Medical School, 567 Baekje-daero, Deokjin-gu, Jeonju, Jeonbuk 54896, Republic of Korea (S.-W. Chae).Metabolically beneficial effects of decursin and decursinol angelate have been reported. However, it is unclear whether Angelica gigas Nakai extract (AGNE), which is rich in decursin and decursinol angelate, can alleviate high-fat diet (HFD)-mediated non-alcoholic fatty liver disease and dyslipidemia. In this study, c57BL6/J mice were fed a HFD, or HFD with various doses of AGNE for 16 weeks. Supplementation with AGNE attenuated glucose and insulin intolerance, hepatic steatosis and inflammation, and hypertriglyceridemia induced by the HFD. AGNE significantly suppressed hepatic de novo lipogenesis through activation of adenosine monophosphate-activated protein kinase (AMPK). HepG2 cells treated with free fatty acid mixture (oleate:palmitate = 2:1) displayed increases of de novo lipogenesis and consequent lipid droplet formation. Addition of decursin or decursinol angelate increased Sirt1 expression, which suppressed lipid accumulation in HepG2 cells. These results indicate that the metabolic effects of AGNE may be related to the induction of Sirt1 and consequent activation of AMPK.http://www.sciencedirect.com/science/article/pii/S1756464617300804Angelica gigas NakaiDecursinDecursinol angelateLipogenesisSirt1NAFLD |
| spellingShingle | Ui-Jin Bae Mi-Ra Oh Tae-Sung Jung Soo-Wan Chae Byung-Hyun Park Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet Journal of Functional Foods Angelica gigas Nakai Decursin Decursinol angelate Lipogenesis Sirt1 NAFLD |
| title | Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| title_full | Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| title_fullStr | Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| title_full_unstemmed | Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| title_short | Decursin and decursinol angelate-rich Angelica gigas Nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| title_sort | decursin and decursinol angelate rich angelica gigas nakai extract suppresses de novo lipogenesis and alleviates nonalcoholic fatty liver disease and dyslipidemia in mice fed a high fat diet |
| topic | Angelica gigas Nakai Decursin Decursinol angelate Lipogenesis Sirt1 NAFLD |
| url | http://www.sciencedirect.com/science/article/pii/S1756464617300804 |
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