Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling

Abstract Background Lung metastasis is the most adverse clinical factor and remains the leading cause of osteosarcoma-related death. Deciphering the mechanisms driving metastatic spread is crucial for finding open therapeutic windows for successful organ-specific interventions that may halt or preve...

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Bibliographic Details
Main Authors: Sara F.F. Almeida, Liliana Santos, Gabriela Sampaio-Ribeiro, Hugo R.S. Ferreira, Nuno Lima, Rui Caetano, Mónica Abreu, Mónica Zuzarte, Ana Sofia Ribeiro, Artur Paiva, Tânia Martins-Marques, Paulo Teixeira, Rui Almeida, José Manuel Casanova, Henrique Girão, Antero J. Abrunhosa, Célia M. Gomes
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Osteosarcoma
Lung Metastasis
Premetastatic niche
Extracellular matrix
Neutrophils
Fibroblasts
Online Access:https://doi.org/10.1186/s13046-023-02886-9

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