Should Endometrial Cancer Treatment Be Centralized?
Endometrial cancer (EC) is the most common malignancy of the female genital tract in Western and emerging countries. In 2012, new cancer cases numbered 319,605, and 76,160 cancer deaths were diagnosed worldwide. ECs are usually diagnosed after menopause; 70% of ECs are diagnosed at an early stage wi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/5/768 |
| _version_ | 1797501423632515072 |
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| author | Vincenzo Dario Mandato Andrea Palicelli Federica Torricelli Valentina Mastrofilippo Chiara Leone Vittoria Dicarlo Alessandro Tafuni Giacomo Santandrea Gianluca Annunziata Matteo Generali Debora Pirillo Gino Ciarlini Lorenzo Aguzzoli |
| author_facet | Vincenzo Dario Mandato Andrea Palicelli Federica Torricelli Valentina Mastrofilippo Chiara Leone Vittoria Dicarlo Alessandro Tafuni Giacomo Santandrea Gianluca Annunziata Matteo Generali Debora Pirillo Gino Ciarlini Lorenzo Aguzzoli |
| author_sort | Vincenzo Dario Mandato |
| collection | DOAJ |
| description | Endometrial cancer (EC) is the most common malignancy of the female genital tract in Western and emerging countries. In 2012, new cancer cases numbered 319,605, and 76,160 cancer deaths were diagnosed worldwide. ECs are usually diagnosed after menopause; 70% of ECs are diagnosed at an early stage with a favorable prognosis and a 5-year overall survival rate of 77%. On the contrary, women with advanced or recurrent disease have extremely poor outcomes because they show a low response rate to conventional chemotherapy. EC is generally considered easy to treat, although it presents a 5-year mortality of 25%. Though the guidelines (GLs) recommend treatment in specialized centers by physicians specializing in gynecologic oncology, most women are managed by general gynecologists, resulting in differences and discrepancies in clinical management. In this paper we reviewed the literature with the aim of highlighting where the treatment of EC patients requires gynecologic oncologists, as suggested by the GLs. Moreover, we sought to identify the causes of the lack of GL adherence, suggesting useful changes to ensure adequate treatment for all EC patients. |
| first_indexed | 2024-03-10T03:18:12Z |
| format | Article |
| id | doaj.art-2ba3e6e376c144179cecbd2be88dde03 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T03:18:12Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-2ba3e6e376c144179cecbd2be88dde032023-11-23T10:08:10ZengMDPI AGBiology2079-77372022-05-0111576810.3390/biology11050768Should Endometrial Cancer Treatment Be Centralized?Vincenzo Dario Mandato0Andrea Palicelli1Federica Torricelli2Valentina Mastrofilippo3Chiara Leone4Vittoria Dicarlo5Alessandro Tafuni6Giacomo Santandrea7Gianluca Annunziata8Matteo Generali9Debora Pirillo10Gino Ciarlini11Lorenzo Aguzzoli12Unit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyLaboratory of Translational Research, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Obstetrics and Gynecology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Surgical Gynecol Oncology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyUnit of Surgical Gynecol Oncology, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, ItalyEndometrial cancer (EC) is the most common malignancy of the female genital tract in Western and emerging countries. In 2012, new cancer cases numbered 319,605, and 76,160 cancer deaths were diagnosed worldwide. ECs are usually diagnosed after menopause; 70% of ECs are diagnosed at an early stage with a favorable prognosis and a 5-year overall survival rate of 77%. On the contrary, women with advanced or recurrent disease have extremely poor outcomes because they show a low response rate to conventional chemotherapy. EC is generally considered easy to treat, although it presents a 5-year mortality of 25%. Though the guidelines (GLs) recommend treatment in specialized centers by physicians specializing in gynecologic oncology, most women are managed by general gynecologists, resulting in differences and discrepancies in clinical management. In this paper we reviewed the literature with the aim of highlighting where the treatment of EC patients requires gynecologic oncologists, as suggested by the GLs. Moreover, we sought to identify the causes of the lack of GL adherence, suggesting useful changes to ensure adequate treatment for all EC patients.https://www.mdpi.com/2079-7737/11/5/768endometrial cancergynecologic oncologistsgeneral gynecologistscentralizationlymphadenectomysentinel lymph node biopsy |
| spellingShingle | Vincenzo Dario Mandato Andrea Palicelli Federica Torricelli Valentina Mastrofilippo Chiara Leone Vittoria Dicarlo Alessandro Tafuni Giacomo Santandrea Gianluca Annunziata Matteo Generali Debora Pirillo Gino Ciarlini Lorenzo Aguzzoli Should Endometrial Cancer Treatment Be Centralized? Biology endometrial cancer gynecologic oncologists general gynecologists centralization lymphadenectomy sentinel lymph node biopsy |
| title | Should Endometrial Cancer Treatment Be Centralized? |
| title_full | Should Endometrial Cancer Treatment Be Centralized? |
| title_fullStr | Should Endometrial Cancer Treatment Be Centralized? |
| title_full_unstemmed | Should Endometrial Cancer Treatment Be Centralized? |
| title_short | Should Endometrial Cancer Treatment Be Centralized? |
| title_sort | should endometrial cancer treatment be centralized |
| topic | endometrial cancer gynecologic oncologists general gynecologists centralization lymphadenectomy sentinel lymph node biopsy |
| url | https://www.mdpi.com/2079-7737/11/5/768 |
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