Effects of Chronic LY341495 on Hippocampal mTORC1 Signaling in Mice with Chronic Unpredictable Stress-Induced Depression

Effects of Chronic LY341495 on Hippocampal mTORC1 Signaling in Mice with Chronic Unpredictable Stress-Induced Depression

In several rodent models, acute administration of the metabotropic glutamate 2/3 (mGlu2/3) receptor antagonist LY341495 induced antidepressant-like effects via a mechanism of action similar to that of ketamine. However, the effects of chronic mGlu2/3 antagonism have not yet been explored. Therefore,...

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Bibliographic Details
Main Authors:	Mi Kyoung Seo, Jung An Lee, Sehoon Jeong, Dae-Hyun Seog, Jung Goo Lee, Sung Woo Park
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	International Journal of Molecular Sciences
Subjects:	chronic unpredictable stress depression hippocampus LY341495 mTORC1
Online Access:	https://www.mdpi.com/1422-0067/23/12/6416

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