Fraxinol attenuates LPS-induced acute lung injury by equilibrating ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas and inhibiting NLRP3

Fraxinol attenuates LPS-induced acute lung injury by equilibrating ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas and inhibiting NLRP3

Context Acute lung injury (ALI) is a serious heterogenous pulmonary disorder. Fraxinol was selected for this study since it is a simple coumarin compound, not previously investigated in ALI.Objectives This study investigates the ALI therapeutic effect and mechanisms of fraxinol.Materials and methods...

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Bibliographic Details
Main Authors: Yan Wu, Xin Yang, Yuanyuan Ju, Fei Zhao
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Pharmaceutical Biology
Subjects:
Inflammation
apoptosis
renin-angiotensin system
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2022.2067571

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