Characterization and performance evaluation of the first-proton therapy facility in India
Purpose: The purpose of this study is to evaluate the performance characteristic of volumetric image-guided dedicated-nozzle pencil beam-scanning proton therapy (PT) system. Materials and Methods: PT system was characterized for electromechanical, image quality, and registration accuracy. Proton bea...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Journal of Medical Physics |
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| Online Access: | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2020;volume=45;issue=2;spage=59;epage=65;aulast=Shamurailatpam |
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| author | Dayananda Sharma Shamurailatpam A Manikandan K Ganapathy M P Noufal Kartikeshwar C Patro T Rajesh R Jalali |
| author_facet | Dayananda Sharma Shamurailatpam A Manikandan K Ganapathy M P Noufal Kartikeshwar C Patro T Rajesh R Jalali |
| author_sort | Dayananda Sharma Shamurailatpam |
| collection | DOAJ |
| description | Purpose: The purpose of this study is to evaluate the performance characteristic of volumetric image-guided dedicated-nozzle pencil beam-scanning proton therapy (PT) system. Materials and Methods: PT system was characterized for electromechanical, image quality, and registration accuracy. Proton beam of 70.2–226.2 MeV was characterized for short- and long-term reproducibility in integrated depth dose; spot profile characteristics at different air gap and gantry angle; positioning accuracy of single and pattern of spot; dose linearity, reproducibility and consistency. All measurements were carried out using various X-ray and proton-beam specific detectors following standard protocols. Results: All electro-mechanical, imaging, and safety parameters performed well within the specified tolerance limit. The image registration errors along three translation and three rotational axes were ≤0.5 mm and ≤0.2° for both point-based and intensity-based auto-registration. Distal range (R90) and distal dose fall-off (DDF) of 70.2–226.2 MeV proton beams were within 1 mm of calculated values based on the international commission on radiation units and measurements 49 and 0.0156× R90, respectively. The R90and DDF were reproducible within a standard deviation of 0.05 g/cm2 during the first 8 months. Dose were linear from 18.5 (0.011 MU/spot) to 8405 (5 MU/spot) MU, reproducible within 0.5% in 5 consecutive days and consistent within 0.8% for full rotation. The cGy/MU for 70.2–226.2MeV was consistent within 0.5%. In-air X(Y) spot-sigma at isocenter varies from 2.96 (3.00) mm to 6.68 (6.52) mm for 70.2–226.2 MeV. Maximum variation of spot-sigma with air-gap of ±20 cm was ±0.36 mm (5.28%) and ±0.82 mm (±12.5%) along X- and Y-direction and 3.56% for full rotation. Relative spot positions were accurate within ±0.6 mm. The planned and delivered spot pattern of known complex geometry agreed with (γ%≤1) for 1% @ 1 mm >98% for representative five-proton energies at four gantry angle. Conclusion: The PT-system performed well within the expected accuracy level and consistent over a period of 8 months. The methodology and data presented here may help upcoming modern PT center during their crucial phase of commissioning. |
| first_indexed | 2024-04-13T06:34:29Z |
| format | Article |
| id | doaj.art-2baaf67d835f430f83a8d0f2af958043 |
| institution | Directory Open Access Journal |
| issn | 0971-6203 1998-3913 |
| language | English |
| last_indexed | 2024-04-13T06:34:29Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Medical Physics |
| spelling | doaj.art-2baaf67d835f430f83a8d0f2af9580432022-12-22T02:57:59ZengWolters Kluwer Medknow PublicationsJournal of Medical Physics0971-62031998-39132020-01-01452596510.4103/jmp.JMP_12_20Characterization and performance evaluation of the first-proton therapy facility in IndiaDayananda Sharma ShamurailatpamA ManikandanK GanapathyM P NoufalKartikeshwar C PatroT RajeshR JalaliPurpose: The purpose of this study is to evaluate the performance characteristic of volumetric image-guided dedicated-nozzle pencil beam-scanning proton therapy (PT) system. Materials and Methods: PT system was characterized for electromechanical, image quality, and registration accuracy. Proton beam of 70.2–226.2 MeV was characterized for short- and long-term reproducibility in integrated depth dose; spot profile characteristics at different air gap and gantry angle; positioning accuracy of single and pattern of spot; dose linearity, reproducibility and consistency. All measurements were carried out using various X-ray and proton-beam specific detectors following standard protocols. Results: All electro-mechanical, imaging, and safety parameters performed well within the specified tolerance limit. The image registration errors along three translation and three rotational axes were ≤0.5 mm and ≤0.2° for both point-based and intensity-based auto-registration. Distal range (R90) and distal dose fall-off (DDF) of 70.2–226.2 MeV proton beams were within 1 mm of calculated values based on the international commission on radiation units and measurements 49 and 0.0156× R90, respectively. The R90and DDF were reproducible within a standard deviation of 0.05 g/cm2 during the first 8 months. Dose were linear from 18.5 (0.011 MU/spot) to 8405 (5 MU/spot) MU, reproducible within 0.5% in 5 consecutive days and consistent within 0.8% for full rotation. The cGy/MU for 70.2–226.2MeV was consistent within 0.5%. In-air X(Y) spot-sigma at isocenter varies from 2.96 (3.00) mm to 6.68 (6.52) mm for 70.2–226.2 MeV. Maximum variation of spot-sigma with air-gap of ±20 cm was ±0.36 mm (5.28%) and ±0.82 mm (±12.5%) along X- and Y-direction and 3.56% for full rotation. Relative spot positions were accurate within ±0.6 mm. The planned and delivered spot pattern of known complex geometry agreed with (γ%≤1) for 1% @ 1 mm >98% for representative five-proton energies at four gantry angle. Conclusion: The PT-system performed well within the expected accuracy level and consistent over a period of 8 months. The methodology and data presented here may help upcoming modern PT center during their crucial phase of commissioning.http://www.jmp.org.in/article.asp?issn=0971-6203;year=2020;volume=45;issue=2;spage=59;epage=65;aulast=Shamurailatpamcharacterizationcommissioningpencil-beam scanningprotonvalidation |
| spellingShingle | Dayananda Sharma Shamurailatpam A Manikandan K Ganapathy M P Noufal Kartikeshwar C Patro T Rajesh R Jalali Characterization and performance evaluation of the first-proton therapy facility in India Journal of Medical Physics characterization commissioning pencil-beam scanning proton validation |
| title | Characterization and performance evaluation of the first-proton therapy facility in India |
| title_full | Characterization and performance evaluation of the first-proton therapy facility in India |
| title_fullStr | Characterization and performance evaluation of the first-proton therapy facility in India |
| title_full_unstemmed | Characterization and performance evaluation of the first-proton therapy facility in India |
| title_short | Characterization and performance evaluation of the first-proton therapy facility in India |
| title_sort | characterization and performance evaluation of the first proton therapy facility in india |
| topic | characterization commissioning pencil-beam scanning proton validation |
| url | http://www.jmp.org.in/article.asp?issn=0971-6203;year=2020;volume=45;issue=2;spage=59;epage=65;aulast=Shamurailatpam |
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