Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats
Purpose : Bee Venom Acupuncture(BVA) is known to affect inflammation and immune system. This study examined the macroscopic, hormonal and immunological effects of BVA on rats with surgically induced endometriosis. Method : Endometrial tissue was implanted in the serosal wall of the small intestine...
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| Format: | Article |
| Language: | English |
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Korean Pharmacopuncture Institute
2006-02-01
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| Series: | Journal of Pharmacopuncture |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3831/KPI.2006.9.1.021 |
| _version_ | 1811193809306910720 |
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| author | Yong-Hyun Lee Eun-Mee Lim Ki-Rok Kwon |
| author_facet | Yong-Hyun Lee Eun-Mee Lim Ki-Rok Kwon |
| author_sort | Yong-Hyun Lee |
| collection | DOAJ |
| description | Purpose : Bee Venom Acupuncture(BVA) is known to affect inflammation and immune system. This study examined the macroscopic, hormonal and immunological effects of BVA on rats with surgically induced endometriosis.
Method : Endometrial tissue was implanted in the serosal wall of the small intestine in rats. The rats were divided randomly into an experimental and control group. The experimental group was treated with BVA injection on kwanwon(CV4) three times per week, and the control group was given an oral dose of normal saline every day. 6 weeks later, the size of the ectopic uterine tissue was estimated, and the serum progesterone, estradiol and cytokine(TNF-α, IL-2, IL-4, IL-6, IL-10) concentrations were analyzed.
Result : The size of the ectopic uterine implants in the experimental group was much smaller than that in the control group. The estradiol, IL-2 concentrations were significantly lower and the IL-6, IL-10 concentrations were significantly higher in the serum of the experimental group than in the control group. there was no significant difference in the concentration of the other cytokine.
Conclusion : These results suggest that BVA is an effective treatment for endometriosis. |
| first_indexed | 2024-04-12T00:15:37Z |
| format | Article |
| id | doaj.art-2bab015d343d45a7971e36701e5edc87 |
| institution | Directory Open Access Journal |
| issn | 2093-6966 2234-6856 |
| language | English |
| last_indexed | 2024-04-12T00:15:37Z |
| publishDate | 2006-02-01 |
| publisher | Korean Pharmacopuncture Institute |
| record_format | Article |
| series | Journal of Pharmacopuncture |
| spelling | doaj.art-2bab015d343d45a7971e36701e5edc872022-12-22T03:55:50ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562006-02-0191213210.3831/KPI.2006.9.1.021 Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in RatsYong-Hyun Lee0Eun-Mee Lim1Ki-Rok Kwon2Dept. of Gynecology, College of Oriental Medicine, Kyungwon UniversityDept. of Gynecology, College of Oriental Medicine, Kyungwon UniversityDept. of Acupuncture and Moxibustion, College of Oriental Medicine, Sangji UniversityPurpose : Bee Venom Acupuncture(BVA) is known to affect inflammation and immune system. This study examined the macroscopic, hormonal and immunological effects of BVA on rats with surgically induced endometriosis. Method : Endometrial tissue was implanted in the serosal wall of the small intestine in rats. The rats were divided randomly into an experimental and control group. The experimental group was treated with BVA injection on kwanwon(CV4) three times per week, and the control group was given an oral dose of normal saline every day. 6 weeks later, the size of the ectopic uterine tissue was estimated, and the serum progesterone, estradiol and cytokine(TNF-α, IL-2, IL-4, IL-6, IL-10) concentrations were analyzed. Result : The size of the ectopic uterine implants in the experimental group was much smaller than that in the control group. The estradiol, IL-2 concentrations were significantly lower and the IL-6, IL-10 concentrations were significantly higher in the serum of the experimental group than in the control group. there was no significant difference in the concentration of the other cytokine. Conclusion : These results suggest that BVA is an effective treatment for endometriosis.http://dx.doi.org/10.3831/KPI.2006.9.1.021bee venom acupunctureendometriosisprogesteroneestradiolcytokine |
| spellingShingle | Yong-Hyun Lee Eun-Mee Lim Ki-Rok Kwon Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats Journal of Pharmacopuncture bee venom acupuncture endometriosis progesterone estradiol cytokine |
| title | Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats |
| title_full | Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats |
| title_fullStr | Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats |
| title_full_unstemmed | Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats |
| title_short | Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis in Rats |
| title_sort | effects of bee venom acupuncture on surgically induced endometriosis in rats |
| topic | bee venom acupuncture endometriosis progesterone estradiol cytokine |
| url | http://dx.doi.org/10.3831/KPI.2006.9.1.021 |
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