Critical role for arginase 2 in obesity-associated pancreatic cancer
Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor gr...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00331-y |
| _version_ | 1818735325868982272 |
|---|---|
| author | Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany |
| author_facet | Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany |
| author_sort | Tamara Zaytouni |
| collection | DOAJ |
| description | Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth. |
| first_indexed | 2024-12-18T00:19:28Z |
| format | Article |
| id | doaj.art-2bac1b53384648ab8ef09add810f760d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T00:19:28Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2bac1b53384648ab8ef09add810f760d2022-12-21T21:27:22ZengNature PortfolioNature Communications2041-17232017-08-018111210.1038/s41467-017-00331-yCritical role for arginase 2 in obesity-associated pancreatic cancerTamara Zaytouni0Pei-Yun Tsai1Daniel S. Hitchcock2Cory D. DuBois3Elizaveta Freinkman4Lin Lin5Vicente Morales-Oyarvide6Patrick J. Lenehan7Brian M. Wolpin8Mari Mino-Kenudson9Eduardo M. Torres10Nicholas Stylopoulos11Clary B. Clish12Nada Y. Kalaany13Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalBroad Institute of Harvard and MITDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalWhitehead Institute for Biomedical ResearchDepartment of Pediatrics, Harvard Medical SchoolDepartment of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical SchoolDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalDepartment of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical SchoolDepartment of Pathology, Massachusetts General Hospital and Harvard Medical SchoolDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical SchoolDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalBroad Institute of Harvard and MITDivision of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s HospitalObesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth.https://doi.org/10.1038/s41467-017-00331-y |
| spellingShingle | Tamara Zaytouni Pei-Yun Tsai Daniel S. Hitchcock Cory D. DuBois Elizaveta Freinkman Lin Lin Vicente Morales-Oyarvide Patrick J. Lenehan Brian M. Wolpin Mari Mino-Kenudson Eduardo M. Torres Nicholas Stylopoulos Clary B. Clish Nada Y. Kalaany Critical role for arginase 2 in obesity-associated pancreatic cancer Nature Communications |
| title | Critical role for arginase 2 in obesity-associated pancreatic cancer |
| title_full | Critical role for arginase 2 in obesity-associated pancreatic cancer |
| title_fullStr | Critical role for arginase 2 in obesity-associated pancreatic cancer |
| title_full_unstemmed | Critical role for arginase 2 in obesity-associated pancreatic cancer |
| title_short | Critical role for arginase 2 in obesity-associated pancreatic cancer |
| title_sort | critical role for arginase 2 in obesity associated pancreatic cancer |
| url | https://doi.org/10.1038/s41467-017-00331-y |
| work_keys_str_mv | AT tamarazaytouni criticalroleforarginase2inobesityassociatedpancreaticcancer AT peiyuntsai criticalroleforarginase2inobesityassociatedpancreaticcancer AT danielshitchcock criticalroleforarginase2inobesityassociatedpancreaticcancer AT coryddubois criticalroleforarginase2inobesityassociatedpancreaticcancer AT elizavetafreinkman criticalroleforarginase2inobesityassociatedpancreaticcancer AT linlin criticalroleforarginase2inobesityassociatedpancreaticcancer AT vicentemoralesoyarvide criticalroleforarginase2inobesityassociatedpancreaticcancer AT patrickjlenehan criticalroleforarginase2inobesityassociatedpancreaticcancer AT brianmwolpin criticalroleforarginase2inobesityassociatedpancreaticcancer AT mariminokenudson criticalroleforarginase2inobesityassociatedpancreaticcancer AT eduardomtorres criticalroleforarginase2inobesityassociatedpancreaticcancer AT nicholasstylopoulos criticalroleforarginase2inobesityassociatedpancreaticcancer AT clarybclish criticalroleforarginase2inobesityassociatedpancreaticcancer AT nadaykalaany criticalroleforarginase2inobesityassociatedpancreaticcancer |