EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS
In this study the results of the investigation of complex treatment with Infliximab and Methotrexate efficacy and safety of 28 patientscomparing with Methotrexate treatment of 41 patients with polyarticular juvenile idiopathic arthritis at the age of 8–17 years are analyzed. The follow-up period was...
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2012-03-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/123 |
| _version_ | 1797696882621808640 |
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| author | V. A. Kel'tsev L. I. Grebenkina S. A. Pyrkova N. S. Pryanichnikova S. A. Goryunov N. V. Lagoda |
| author_facet | V. A. Kel'tsev L. I. Grebenkina S. A. Pyrkova N. S. Pryanichnikova S. A. Goryunov N. V. Lagoda |
| author_sort | V. A. Kel'tsev |
| collection | DOAJ |
| description | In this study the results of the investigation of complex treatment with Infliximab and Methotrexate efficacy and safety of 28 patientscomparing with Methotrexate treatment of 41 patients with polyarticular juvenile idiopathic arthritis at the age of 8–17 years are analyzed. The follow-up period was 1 year. Infliximab was administered according to the following scheme: 0, 2, 6 weeks and then every 8 weeks. The dosage of Infliximab in children with early onset of juvenile idiopathic arthritis was 3,0 mg/kg per infusion. Clinical remission, decrease and normalization of laboratory markers, complete restoration of joints function and improvement of life quality in 57,7% were established after 46 weeks of treatment with Infliximab and Methotrexate comparing with 16% in children treated with Methotrexate monotherapy. |
| first_indexed | 2024-03-12T03:32:32Z |
| format | Article |
| id | doaj.art-2bae079388484bd6ba126633fa3d15f4 |
| institution | Directory Open Access Journal |
| issn | 1682-5527 1682-5535 |
| language | English |
| last_indexed | 2024-03-12T03:32:32Z |
| publishDate | 2012-03-01 |
| publisher | "Paediatrician" Publishers LLC |
| record_format | Article |
| series | Вопросы современной педиатрии |
| spelling | doaj.art-2bae079388484bd6ba126633fa3d15f42023-09-03T13:24:25Zeng"Paediatrician" Publishers LLCВопросы современной педиатрии1682-55271682-55352012-03-01112828910.15690/vsp.v11i2.216123EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITISV. A. Kel'tsev0L. I. Grebenkina1S. A. Pyrkova2N. S. Pryanichnikova3S. A. Goryunov4N. V. Lagoda5Самарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетСамарский государственный медицинский университетIn this study the results of the investigation of complex treatment with Infliximab and Methotrexate efficacy and safety of 28 patientscomparing with Methotrexate treatment of 41 patients with polyarticular juvenile idiopathic arthritis at the age of 8–17 years are analyzed. The follow-up period was 1 year. Infliximab was administered according to the following scheme: 0, 2, 6 weeks and then every 8 weeks. The dosage of Infliximab in children with early onset of juvenile idiopathic arthritis was 3,0 mg/kg per infusion. Clinical remission, decrease and normalization of laboratory markers, complete restoration of joints function and improvement of life quality in 57,7% were established after 46 weeks of treatment with Infliximab and Methotrexate comparing with 16% in children treated with Methotrexate monotherapy.https://vsp.spr-journal.ru/jour/article/view/123дети, ювенильный идиопатический артритлечениеинфликсимабметотрексат |
| spellingShingle | V. A. Kel'tsev L. I. Grebenkina S. A. Pyrkova N. S. Pryanichnikova S. A. Goryunov N. V. Lagoda EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS Вопросы современной педиатрии дети, ювенильный идиопатический артрит лечение инфликсимаб метотрексат |
| title | EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS |
| title_full | EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS |
| title_fullStr | EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS |
| title_full_unstemmed | EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS |
| title_short | EVALUATION OF EFFICACY AND SAFETY OF COMPLEX TREATMENT WITH INFLIXIMAB AND METHOTREXATE COMPARING WITH METHOTREXATE MONOTHERAPY OF CHILDREN WITH JUVENILE POLYARTICULAR IDIOPATHIC ARTHRITIS |
| title_sort | evaluation of efficacy and safety of complex treatment with infliximab and methotrexate comparing with methotrexate monotherapy of children with juvenile polyarticular idiopathic arthritis |
| topic | дети, ювенильный идиопатический артрит лечение инфликсимаб метотрексат |
| url | https://vsp.spr-journal.ru/jour/article/view/123 |
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