Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland
Familial hypercholesterolemia (FH) is the most common monogenic autosomal dominant disorder. FH results in an increased cardiovascular mortality rate. However, cardiovascular risk control factors enable the avoidance of approximately 80% of strokes and cardiovascular diseases. Therefore, early detec...
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MDPI AG
2020-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/10/11/270 |
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| author | Matylda Hennig Agnieszka Brandt-Varma Anna Wołoszyn-Durkiewicz Joanna Bautembach-Minkowska Marta Buraczewska Dominik Świętoń Agnieszka Mickiewicz Andrzej Rynkiewicz Marcin Gruchała Janusz Limon Bartosz Wasąg Magdalena Chmara Mieczysław Walczak Małgorzata Myśliwiec |
| author_facet | Matylda Hennig Agnieszka Brandt-Varma Anna Wołoszyn-Durkiewicz Joanna Bautembach-Minkowska Marta Buraczewska Dominik Świętoń Agnieszka Mickiewicz Andrzej Rynkiewicz Marcin Gruchała Janusz Limon Bartosz Wasąg Magdalena Chmara Mieczysław Walczak Małgorzata Myśliwiec |
| author_sort | Matylda Hennig |
| collection | DOAJ |
| description | Familial hypercholesterolemia (FH) is the most common monogenic autosomal dominant disorder. FH results in an increased cardiovascular mortality rate. However, cardiovascular risk control factors enable the avoidance of approximately 80% of strokes and cardiovascular diseases. Therefore, early detection and implementation of lipid-lowering treatment is essential. In the present study, 57 pediatric patients aged 9.57 ± 3.26 years with FH were enrolled in the study. Researchers checked the lipid profile and performed the ultrasound imaging including intima-media thickness (IMT) measurement and echo (e)-tracking in the study group. Patients were treated with a low-cholesterol diet solely or along with pharmacological treatment with statins. Subsequently, patients were monitored for 12 months. The positive results of dietary treatment were observed in 40 patients. The efficacy of 12 months of nutritional therapy along with pharmacological treatment was reported in 27 patients. We observed a significant decrease in the carotid beta index stiffness and an insignificant decrease in the IMT in the group of patients treated with statins. The obtained data show that statin therapy in children with FH allow for the reduction of the degree of atherosclerotic vessel changes. |
| first_indexed | 2024-03-10T15:05:51Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T15:05:51Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-2bae1ecc8632449497d2c25e24b8223b2023-11-20T19:44:00ZengMDPI AGLife2075-17292020-11-01101127010.3390/life10110270Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in PolandMatylda Hennig0Agnieszka Brandt-Varma1Anna Wołoszyn-Durkiewicz2Joanna Bautembach-Minkowska3Marta Buraczewska4Dominik Świętoń5Agnieszka Mickiewicz6Andrzej Rynkiewicz7Marcin Gruchała8Janusz Limon9Bartosz Wasąg10Magdalena Chmara11Mieczysław Walczak12Małgorzata Myśliwiec13The Department of Paediatrics, Diabetology and Endocrinology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandSurrey and Sussex Healthcare NHS Trust, Canada Avenue, Redhill RH15RH, UKThe Department of Paediatrics, Diabetology and Endocrinology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandThe Department of Paediatrics, Diabetology and Endocrinology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandThe Department of Neonatology, Specialized Hospital in Wejherowo, 84-200 Wejherowo, PolandThe Department of Radiology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandThe Department of Cardiology I, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandThe Department of Cardiology and Cardiosurgery, Ist Cardiology Clinic, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, PolandThe Department of Cardiology I, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandThe Department of Biology and Genetics, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdansk, PolandThe Department of Biology and Genetics, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdansk, PolandThe Department of Biology and Genetics, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdansk, PolandThe Department of Paediatrics, Endocrinology, Diabetology, Metabolic Diseases and Developmental Cardiology, Faculty of Medicine, Pomeranian Medical University, 70-204 Szczecin, PolandThe Department of Paediatrics, Diabetology and Endocrinology, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandFamilial hypercholesterolemia (FH) is the most common monogenic autosomal dominant disorder. FH results in an increased cardiovascular mortality rate. However, cardiovascular risk control factors enable the avoidance of approximately 80% of strokes and cardiovascular diseases. Therefore, early detection and implementation of lipid-lowering treatment is essential. In the present study, 57 pediatric patients aged 9.57 ± 3.26 years with FH were enrolled in the study. Researchers checked the lipid profile and performed the ultrasound imaging including intima-media thickness (IMT) measurement and echo (e)-tracking in the study group. Patients were treated with a low-cholesterol diet solely or along with pharmacological treatment with statins. Subsequently, patients were monitored for 12 months. The positive results of dietary treatment were observed in 40 patients. The efficacy of 12 months of nutritional therapy along with pharmacological treatment was reported in 27 patients. We observed a significant decrease in the carotid beta index stiffness and an insignificant decrease in the IMT in the group of patients treated with statins. The obtained data show that statin therapy in children with FH allow for the reduction of the degree of atherosclerotic vessel changes.https://www.mdpi.com/2075-1729/10/11/270hypercholesterolemiacarotid intima-media thicknesscardiovascular diseaseatherosclerosis |
| spellingShingle | Matylda Hennig Agnieszka Brandt-Varma Anna Wołoszyn-Durkiewicz Joanna Bautembach-Minkowska Marta Buraczewska Dominik Świętoń Agnieszka Mickiewicz Andrzej Rynkiewicz Marcin Gruchała Janusz Limon Bartosz Wasąg Magdalena Chmara Mieczysław Walczak Małgorzata Myśliwiec Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland Life hypercholesterolemia carotid intima-media thickness cardiovascular disease atherosclerosis |
| title | Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland |
| title_full | Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland |
| title_fullStr | Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland |
| title_full_unstemmed | Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland |
| title_short | Monitoring the Effects of Hypolipidemic Treatment in Children with Familial Hypercholesterolemia in Poland |
| title_sort | monitoring the effects of hypolipidemic treatment in children with familial hypercholesterolemia in poland |
| topic | hypercholesterolemia carotid intima-media thickness cardiovascular disease atherosclerosis |
| url | https://www.mdpi.com/2075-1729/10/11/270 |
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