Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
Abstract Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12944-020-01286-8 |
| _version_ | 1818907451974483968 |
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| author | Katarzyna Kolczynska Angel Loza-Valdes Izabela Hawro Grzegorz Sumara |
| author_facet | Katarzyna Kolczynska Angel Loza-Valdes Izabela Hawro Grzegorz Sumara |
| author_sort | Katarzyna Kolczynska |
| collection | DOAJ |
| description | Abstract Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes. |
| first_indexed | 2024-12-19T21:55:20Z |
| format | Article |
| id | doaj.art-2bafef4432634073bac0c668d830c983 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-12-19T21:55:20Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-2bafef4432634073bac0c668d830c9832022-12-21T20:04:17ZengBMCLipids in Health and Disease1476-511X2020-05-0119111510.1186/s12944-020-01286-8Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a reviewKatarzyna Kolczynska0Angel Loza-Valdes1Izabela Hawro2Grzegorz Sumara3Nencki Institute of Experimental Biology, Polish Academy of SciencesNencki Institute of Experimental Biology, Polish Academy of SciencesNencki Institute of Experimental Biology, Polish Academy of SciencesNencki Institute of Experimental Biology, Polish Academy of SciencesAbstract Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.http://link.springer.com/article/10.1186/s12944-020-01286-8Diacylglycerol (DAG)PKCPKDMetabolismInsulin signaling |
| spellingShingle | Katarzyna Kolczynska Angel Loza-Valdes Izabela Hawro Grzegorz Sumara Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review Lipids in Health and Disease Diacylglycerol (DAG) PKC PKD Metabolism Insulin signaling |
| title | Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review |
| title_full | Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review |
| title_fullStr | Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review |
| title_full_unstemmed | Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review |
| title_short | Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review |
| title_sort | diacylglycerol evoked activation of pkc and pkd isoforms in regulation of glucose and lipid metabolism a review |
| topic | Diacylglycerol (DAG) PKC PKD Metabolism Insulin signaling |
| url | http://link.springer.com/article/10.1186/s12944-020-01286-8 |
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