High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition

High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition

Background/Aims: Abnormal QT prolongation is the most prominent cardiac electrical disturbance in patients with diabetes mellitus (DM). It is well known that the human ether-ago-go-related gene (hERG) controls the rapid delayed rectifier K+ current (IKr) in cardiac cells. The expression of the hERG...

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Bibliographic Details
Main Authors:	Yuan-Qi Shi, Meng Yan, Li-Rong Liu, Xiao Zhang, Xue Wang, Huai-Ze Geng, Xin Zhao, Bao-Xin Li
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2015-08-01
Series:	Cellular Physiology and Biochemistry
Subjects:	Diabetes mellitus High-glucose hERG LQT Unfolded protein response Insulin
Online Access:	http://www.karger.com/Article/FullText/430353

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