Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms
Background/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. The aim of this study was to evaluate the outcome...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Gastrointestinal Endoscopy
2016-03-01
|
| Series: | Clinical Endoscopy |
| Subjects: | |
| Online Access: | http://www.e-ce.org/upload/pdf/ce-2015-080.pdf |
| _version_ | 1797423477115846656 |
|---|---|
| author | Jung Soo Park Young Hoon Youn Jae Jun Park Jie-Hyun Kim Hyojin Park |
| author_facet | Jung Soo Park Young Hoon Youn Jae Jun Park Jie-Hyun Kim Hyojin Park |
| author_sort | Jung Soo Park |
| collection | DOAJ |
| description | Background/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. The aim of this study was to evaluate the outcomes of ESD for superficial esophageal neoplasms. Methods: We retrospectively reviewed 36 esophageal ESDs for superficial squamous neoplasms in 32 patients between March 2009 and August 2014 at Gangnam Severance Hospital. Results: The median patient age was 64 years, and 30 men were included. The indications were early squamous cell carcinoma in 26 lesions, adenoma with high-grade dysplasia in five lesions, and low-grade dysplasia in five lesions. The en bloc resection and R0 resection rates were 97.2% (35 of 36) and 91.7% (33 of 36), respectively. Microperforation and post-ESD bleeding occurred in 5.6% (2 of 36) and 5.6% (2 of 36), respectively. Post-ESD esophageal strictures developed in five patients (13.9%). Five patients (15.6%) had an additional treatment after ESD (concurrent chemoradiation therapy in three, radiation therapy in one, and surgery in one patient). There was no disease-specific mortality during the median follow-up of 31 months. Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD could be a good treatment option in terms of efficacy and safety. |
| first_indexed | 2024-03-09T07:48:25Z |
| format | Article |
| id | doaj.art-2bb16e7119894d4f97e6972823186f8b |
| institution | Directory Open Access Journal |
| issn | 2234-2400 2234-2443 |
| language | English |
| last_indexed | 2024-03-09T07:48:25Z |
| publishDate | 2016-03-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj.art-2bb16e7119894d4f97e6972823186f8b2023-12-03T02:22:06ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432016-03-0149216817510.5946/ce.2015.0806833Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous NeoplasmsJung Soo ParkYoung Hoon YounJae Jun ParkJie-Hyun KimHyojin ParkBackground/Aims: Endoscopic treatment has been broadly applied to superficial esophageal neoplasms. Endoscopic submucosal dissection (ESD) allows for high rates of en bloc resection, precise histological assessment, and low rates of local recurrence. The aim of this study was to evaluate the outcomes of ESD for superficial esophageal neoplasms. Methods: We retrospectively reviewed 36 esophageal ESDs for superficial squamous neoplasms in 32 patients between March 2009 and August 2014 at Gangnam Severance Hospital. Results: The median patient age was 64 years, and 30 men were included. The indications were early squamous cell carcinoma in 26 lesions, adenoma with high-grade dysplasia in five lesions, and low-grade dysplasia in five lesions. The en bloc resection and R0 resection rates were 97.2% (35 of 36) and 91.7% (33 of 36), respectively. Microperforation and post-ESD bleeding occurred in 5.6% (2 of 36) and 5.6% (2 of 36), respectively. Post-ESD esophageal strictures developed in five patients (13.9%). Five patients (15.6%) had an additional treatment after ESD (concurrent chemoradiation therapy in three, radiation therapy in one, and surgery in one patient). There was no disease-specific mortality during the median follow-up of 31 months. Conclusions: Favorable clinical outcomes were observed in ESD for superficial esophageal squamous neoplasms. Esophageal ESD could be a good treatment option in terms of efficacy and safety.http://www.e-ce.org/upload/pdf/ce-2015-080.pdfEndoscopic submucosal dissectionEsophageal neoplasmsCarcinoma, squamous cellTreatment outcomeComplications |
| spellingShingle | Jung Soo Park Young Hoon Youn Jae Jun Park Jie-Hyun Kim Hyojin Park Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms Clinical Endoscopy Endoscopic submucosal dissection Esophageal neoplasms Carcinoma, squamous cell Treatment outcome Complications |
| title | Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms |
| title_full | Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms |
| title_fullStr | Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms |
| title_full_unstemmed | Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms |
| title_short | Clinical Outcomes of Endoscopic Submucosal Dissection for Superficial Esophageal Squamous Neoplasms |
| title_sort | clinical outcomes of endoscopic submucosal dissection for superficial esophageal squamous neoplasms |
| topic | Endoscopic submucosal dissection Esophageal neoplasms Carcinoma, squamous cell Treatment outcome Complications |
| url | http://www.e-ce.org/upload/pdf/ce-2015-080.pdf |
| work_keys_str_mv | AT jungsoopark clinicaloutcomesofendoscopicsubmucosaldissectionforsuperficialesophagealsquamousneoplasms AT younghoonyoun clinicaloutcomesofendoscopicsubmucosaldissectionforsuperficialesophagealsquamousneoplasms AT jaejunpark clinicaloutcomesofendoscopicsubmucosaldissectionforsuperficialesophagealsquamousneoplasms AT jiehyunkim clinicaloutcomesofendoscopicsubmucosaldissectionforsuperficialesophagealsquamousneoplasms AT hyojinpark clinicaloutcomesofendoscopicsubmucosaldissectionforsuperficialesophagealsquamousneoplasms |