Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis
Introduction The familiality of intelligence quotient (IQ), understood as its similarity among family members, might be related to different manifestations in first episode of psychosis (FEP) patients. Objectives To estimate the IQ familiality through the intra-family resemblance score (IRS) in F...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822003200/type/journal_article |
| _version_ | 1797616985558745088 |
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| author | N. Murillo-García J. Soler M. Fatjó-Vilas R. Ayesa-Arriola |
| author_facet | N. Murillo-García J. Soler M. Fatjó-Vilas R. Ayesa-Arriola |
| author_sort | N. Murillo-García |
| collection | DOAJ |
| description |
Introduction
The familiality of intelligence quotient (IQ), understood as its similarity among family members, might be related to different manifestations in first episode of psychosis (FEP) patients.
Objectives
To estimate the IQ familiality through the intra-family resemblance score (IRS) in FEP patients and their unaffected first-degree relatives; and to analyze if the deviation from the family-IQ is related to the patients’ premorbid, clinical and cognitive characteristics.
Methods
Individuals from 129 families participated in this study (129 patients, 143 parents, 97 siblings). For each family, two values were estimated: the family-IQ, obtained by the mean IQ of the patient and his/her relatives (using the WAIS vocabulary subtest); and the IRS, an index previously reported that indicate intra-family heterogeneity (IRS<0) or homogeneity (IRS>0) for a given trait. According to the IRS and the family-IQ, patients were assigned to 6 groups (Figure 1).
Results
FEP patients in families with heterogeneous IQ (IRS<0) had a significantly lower IQ than their relatives (p<0.001). Also, those with low IQ and from heterogeneous families had poorer childhood adjustment (p=0.001). The patients with high IQ belonging to homogenous families showed less positive symptoms at baseline (p=0.009). FEP patients in homogenous families due to low IQ evidenced the lowest neuropsychological performance (Figure 2).
Conclusions
The analysis of the IQ familiality and the concordance/discordance of the patients’ and relatives’ IQ, offers a new approach for the characterization of different premorbid, clinical and cognitive profiles in FEP patients. The relationship between deviation from the family-IQ and poor premorbid childhood adjustment supports the neurodevelopmental hypothesis of schizophrenia.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:49:03Z |
| format | Article |
| id | doaj.art-2bb199c336044b40a0d5aa951568ebc7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:49:03Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-2bb199c336044b40a0d5aa951568ebc72023-11-17T05:07:04ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S114S11510.1192/j.eurpsy.2022.320Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosisN. Murillo-García0J. Soler1M. Fatjó-Vilas2R. Ayesa-Arriola3IDIVAL, Valdecilla Biomedical Research, Research Group On Mental Illnesses, Santander, SpainUniversity of Barcelona, Department Of Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, SpainCIBERSAM, Center for Biomedical Research in Mental Health Network, Mental Health, Madrid, SpainValdecilla Biomedical Research Institute, Psychiatry, Santander, Spain Introduction The familiality of intelligence quotient (IQ), understood as its similarity among family members, might be related to different manifestations in first episode of psychosis (FEP) patients. Objectives To estimate the IQ familiality through the intra-family resemblance score (IRS) in FEP patients and their unaffected first-degree relatives; and to analyze if the deviation from the family-IQ is related to the patients’ premorbid, clinical and cognitive characteristics. Methods Individuals from 129 families participated in this study (129 patients, 143 parents, 97 siblings). For each family, two values were estimated: the family-IQ, obtained by the mean IQ of the patient and his/her relatives (using the WAIS vocabulary subtest); and the IRS, an index previously reported that indicate intra-family heterogeneity (IRS<0) or homogeneity (IRS>0) for a given trait. According to the IRS and the family-IQ, patients were assigned to 6 groups (Figure 1). Results FEP patients in families with heterogeneous IQ (IRS<0) had a significantly lower IQ than their relatives (p<0.001). Also, those with low IQ and from heterogeneous families had poorer childhood adjustment (p=0.001). The patients with high IQ belonging to homogenous families showed less positive symptoms at baseline (p=0.009). FEP patients in homogenous families due to low IQ evidenced the lowest neuropsychological performance (Figure 2). Conclusions The analysis of the IQ familiality and the concordance/discordance of the patients’ and relatives’ IQ, offers a new approach for the characterization of different premorbid, clinical and cognitive profiles in FEP patients. The relationship between deviation from the family-IQ and poor premorbid childhood adjustment supports the neurodevelopmental hypothesis of schizophrenia. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822003200/type/journal_articleFamilial aggregationIntelligence QuotientNeurocognitionFirst episode of psychosis |
| spellingShingle | N. Murillo-García J. Soler M. Fatjó-Vilas R. Ayesa-Arriola Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis European Psychiatry Familial aggregation Intelligence Quotient Neurocognition First episode of psychosis |
| title | Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis |
| title_full | Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis |
| title_fullStr | Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis |
| title_full_unstemmed | Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis |
| title_short | Family aggregation of the Intelligence Quotient: understanding its role in first episode of psychosis |
| title_sort | family aggregation of the intelligence quotient understanding its role in first episode of psychosis |
| topic | Familial aggregation Intelligence Quotient Neurocognition First episode of psychosis |
| url | https://www.cambridge.org/core/product/identifier/S0924933822003200/type/journal_article |
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