Role of Prophylactic Antibiotic Administration in Growth of Methicillin Resistant Staphylococcus Aureus in Rhinoplasty
Background: Septoplasty and septorhinoplasty are common surgical procedures in modern surgical practice. Pre or postoperative antibiotic administration has raised concerns about the possible increase in the antibiotic-resistant species. The aim of this study was to evaluate the role of postoperat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shaheed Beheshti University of Medical Sciences
2019-07-01
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| Series: | International Journal of Medical Toxicology and Forensic Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/ijmtfm/article/view/25228/pdf |
| Summary: | Background: Septoplasty and septorhinoplasty are common surgical procedures in modern
surgical practice. Pre or postoperative antibiotic administration has raised concerns about the
possible increase in the antibiotic-resistant species. The aim of this study was to evaluate the
role of postoperative antibiotic prophylaxis in increasing Methicillin-Resistant Staphylococcus
Aaureus species (MRSA) in patients, who underwent septoplasty or septorhinoplasty in
Loghman Hakim Hospital in Tehran, Iran.
Methods: A total of 102 patients, who were planned to undergo septoplasty or septorhinoplasty,
participated in this double-blind randomized clinical trial. The patients were divided into the
case (n=60, mean age of 28.2 years) and control (n=38, mean age of 28.9 years) groups.
Overall, 98 patients participated in the study. The case group received a preoperative injection
of cephalothin (1g) and postoperative oral cephalexin regimen (500mg 4 times a day for 7
days). The control group only received a preoperative injection of cephalothin (1g). Vestibular
nasal swab cultures were obtained preoperatively and on postoperative day 7. The samples
were, then, quickly transferred to the laboratory and cultured on proper media. The results
indicated that five MRSA species in the case group and tow MRSA species in the control group
were present, postoperatively.
Results: The findings of this study suggest that oral antibiotic prophylaxis may lead to a
statically non-significant increase in MRSA infection in patients, who require this treatment.
Conclusion: Further knowledge of the endogenous nasal flora and the microbiology of
common pathogens in patients undergoing septorhinoplasty will help reduce the incidence of
infectious complications to a greater level. |
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| ISSN: | 2251-8762 2251-8770 |