Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study
Aims and Objectives: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. Materials and Methods: In this prospective study, 140 eyes of 70 pati...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2023-01-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=6;spage=1257;epage=1261;aulast=Arora |
| _version_ | 1797738511080620032 |
|---|---|
| author | Priyanka Arora Ashima Goyal Madhushmita Mahapatra Kamaldeep Arora Ritesh Verma |
| author_facet | Priyanka Arora Ashima Goyal Madhushmita Mahapatra Kamaldeep Arora Ritesh Verma |
| author_sort | Priyanka Arora |
| collection | DOAJ |
| description | Aims and Objectives: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. Materials and Methods: In this prospective study, 140 eyes of 70 patients (aged 5–40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants. Results: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064). Conclusion: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia. |
| first_indexed | 2024-03-12T13:43:50Z |
| format | Article |
| id | doaj.art-2bb2c694c9bf4343be6aa731955e8e3f |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-03-12T13:43:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-2bb2c694c9bf4343be6aa731955e8e3f2023-08-23T09:45:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062023-01-011561257126110.4103/jpbs.jpbs_132_23Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional studyPriyanka AroraAshima GoyalMadhushmita MahapatraKamaldeep AroraRitesh VermaAims and Objectives: To determine the choroidal thickness (mainly subfoveal) using spectral domain optical coherence tomography (SD-OCT) in amblyopic eyes and to compare it with the choroidal thickness (CT) of healthy fellow eyes. Materials and Methods: In this prospective study, 140 eyes of 70 patients (aged 5–40 years) with strabismic and anisometropic amblyopia were examined using enhanced depth imaging (EDI) mode in SD-OCT. The CT was measured directly below the fovea and six other locations: 500 μ, 1000 μ, and 1500 μ from fovea in both nasal and temporal quadrants. Results: The mean age of the patients was 22.5 ± 11.2 years. The mean Best Corrected Visual Acuity (BCVA) in the amblyopic eyes was 0.87 ± 0.47 logMAR and 0 ± 0.02 logMAR in control eyes. The average subfoveal CT was 341.73 ± 60.39 μm in the amblyopic eyes and 314.77 ± 48.12 μm in the fellow eyes. Subgroup analysis showed that the patients with anisometropic amblyopia had a significantly thicker choroid as compared to the fellow healthy eyes (P = 0.00), whereas in strabismic amblyopic eyes, this difference was not significantly significant (P = 0.064). Conclusion: Significant choroidal thickening was observed in subjects with amblyopia, which may contribute to the amblyopia pathogenesis and this could be used as a diagnostic parameter for amblyopia. These changes were more pronounced in patients with anisometropic amblyopia than strabismic amblyopia.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=6;spage=1257;epage=1261;aulast=Aroraamblyopiaanisometropic amblyopiachoroidal thicknessstrabismic amblyopiasubfoveal |
| spellingShingle | Priyanka Arora Ashima Goyal Madhushmita Mahapatra Kamaldeep Arora Ritesh Verma Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study Journal of Pharmacy and Bioallied Sciences amblyopia anisometropic amblyopia choroidal thickness strabismic amblyopia subfoveal |
| title | Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study |
| title_full | Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study |
| title_fullStr | Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study |
| title_full_unstemmed | Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study |
| title_short | Choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia: A prospective cross-sectional study |
| title_sort | choroidal thickness in patients with unilateral amblyopia and comparison between anisometropic and strabismic amblyopia a prospective cross sectional study |
| topic | amblyopia anisometropic amblyopia choroidal thickness strabismic amblyopia subfoveal |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2023;volume=15;issue=6;spage=1257;epage=1261;aulast=Arora |
| work_keys_str_mv | AT priyankaarora choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy AT ashimagoyal choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy AT madhushmitamahapatra choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy AT kamaldeeparora choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy AT riteshverma choroidalthicknessinpatientswithunilateralamblyopiaandcomparisonbetweenanisometropicandstrabismicamblyopiaaprospectivecrosssectionalstudy |