Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain

Phosphatidyl-Inositol-3 Kinase Inhibitors Regulate Peptidoglycan-Induced Myeloid Leukocyte Recruitment, Inflammation, and Neurotoxicity in Mouse Brain

Acute brain injury leads to the recruitment and activation of immune cells including resident microglia and infiltrating peripheral myeloid cells (MC), which contribute to the inflammatory response involved in neuronal damage. We previously reported that TLR2 stimulation by peptidoglycan (PGN) from...

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Bibliographic Details
Main Authors: Daniela S. Arroyo, Emilia A. Gaviglio, Javier M. Peralta Ramos, Claudio Bussi, Maria P. Avalos, Liliana M. Cancela, Pablo Iribarren
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
myeloid cells
phosphatidyl-inositol-3 kinase inhibitors
autophagy
peptidoglycan
TLR2
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00770/full

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