Albumin–Methotrexate Prodrug Analogues That Undergo Intracellular Reactivation Following Entrance into Cancerous Glioma Cells
A family of monomodified bovine serum albumin (BSA) linked to methotrexate (MTX) through a variety of spacers was prepared. All analogues were found to be prodrugs having low MTX-inhibitory potencies toward dihydrofolate reductase in a cell-free system. The optimal conjugates regenerated their antip...
Main Authors: | Itzik Cooper, Michal Schnaider-Beeri, Mati Fridkin, Yoram Shechter |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-12-01
|
Series: | Pharmaceutics |
Subjects: | |
Online Access: | https://www.mdpi.com/1999-4923/14/1/71 |
Similar Items
-
Albumin-EDTA-Vanadium Is a Powerful Anti-Proliferative Agent, Following Entrance into Glioma Cells via Caveolae-Mediated Endocytosis
by: Itzik Cooper, et al.
Published: (2021-09-01) -
Cathepsin B-Overexpressed Tumor Cell Activatable Albumin-Binding Doxorubicin Prodrug for Cancer-Targeted Therapy
by: Hanhee Cho, et al.
Published: (2021-12-01) -
Reduction-Responsive Stearyl Alcohol-Cabazitaxel Prodrug Nanoassemblies for Cancer Chemotherapy
by: Yuting Liu, et al.
Published: (2023-01-01) -
The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies
by: Shuo Wang, et al.
Published: (2024-03-01) -
Synthesis of Two Methotrexate Prodrugs for Optimizing Drug Loading into Liposomes
by: Valentina Di Francesco, et al.
Published: (2021-03-01)