Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study
Abstract Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests a...
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15786 |
| _version_ | 1827583889606967296 |
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| author | Nobuyuki Masaki Takeshi Adachi Hirofumi Tomiyama Takahide Kohro Toru Suzuki Tomoko Ishizu Shinichiro Ueda Tsutomu Yamazaki Tomoo Furumoto Kazuomi Kario Teruo Inoue Shinji Koba Yasuhiko Takemoto Takuzo Hano Masataka Sata Yutaka Ishibashi Koichi Node Koji Maemura Yusuke Ohya Taiji Furukawa Hiroshi Ito Yukihito Higashi Akira Yamashina Bonpei Takase |
| author_facet | Nobuyuki Masaki Takeshi Adachi Hirofumi Tomiyama Takahide Kohro Toru Suzuki Tomoko Ishizu Shinichiro Ueda Tsutomu Yamazaki Tomoo Furumoto Kazuomi Kario Teruo Inoue Shinji Koba Yasuhiko Takemoto Takuzo Hano Masataka Sata Yutaka Ishibashi Koichi Node Koji Maemura Yusuke Ohya Taiji Furukawa Hiroshi Ito Yukihito Higashi Akira Yamashina Bonpei Takase |
| author_sort | Nobuyuki Masaki |
| collection | DOAJ |
| description | Abstract Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non‐T2DM]; women, n = 107 [T2DM] and n = 313 [non‐T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5‐year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age‐adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia. |
| first_indexed | 2024-03-08T23:14:12Z |
| format | Article |
| id | doaj.art-2bb76904743d4797b0ee41b3a5e79643 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T23:14:12Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-2bb76904743d4797b0ee41b3a5e796432023-12-15T06:45:51ZengWileyPhysiological Reports2051-817X2023-08-011116n/an/a10.14814/phy2.15786Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B studyNobuyuki Masaki0Takeshi Adachi1Hirofumi Tomiyama2Takahide Kohro3Toru Suzuki4Tomoko Ishizu5Shinichiro Ueda6Tsutomu Yamazaki7Tomoo Furumoto8Kazuomi Kario9Teruo Inoue10Shinji Koba11Yasuhiko Takemoto12Takuzo Hano13Masataka Sata14Yutaka Ishibashi15Koichi Node16Koji Maemura17Yusuke Ohya18Taiji Furukawa19Hiroshi Ito20Yukihito Higashi21Akira Yamashina22Bonpei Takase23Department of Intensive Care Medicine National Defense Medical College Tokorozawa JapanDepartment of Cardiology National Defense Medical College Tokorozawa JapanDepartment of Cardiology Tokyo Medical University Tokyo JapanDepartment of Hospital Planning and Management, Medical Informatics Jichi Medical University School of Medicine Tochigi JapanCardiovascular Medicine University of Leicester Leicester UKCardiovascular Division Institute of Clinical Medicine, University of Tsukuba Ibaraki JapanDepartment of Clinical Pharmacology and Therapeutics University of the Ryukyu School of Medicine Okinawa JapanDepartment of Clinical Epidemiology and Systems, Faculty of Medicine The University of Tokyo Tokyo JapanDepartment of Cardiovascular Medicine Hokkaido University Graduate School of Medicine Sapporo JapanDivision of Cardiovascular Medicine Jichi Medical University School of Medicine Tochigi JapanDokkyo Medical University; Nasu Red Cross Hospital Tochigi JapanDepartment of Medicine, Division of Cardiology Showa University School of Medicine Tokyo JapanDepartment of Internal Medicine and Cardiology Osaka City University Graduate School of Medicine Osaka JapanDepartment of Medical Education and Population‐based Medicine, Postgraduate School of Medicine Wakayama Medical University Wakayama JapanDepartment of Cardiovascular Medicine Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima JapanDepartment of General Medicine Shimane University Faculty of Medicine Shimane JapanDepartment of Cardiovascular Medicine Saga University Saga JapanDepartment of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences Nagasaki University Nagasaki JapanThe Third Department of Internal Medicine University of the Ryukyus Okinawa JapanDepartment of Internal Medicine Teikyo University School of Medicine Tokyo JapanDepartment of Cardiovascular Medicine Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Okayama JapanDepartment of Regenerative Medicine Research Institute for Radiation Biology and Medicine, Hiroshima University Hiroshima JapanDepartment of Cardiology Tokyo Medical University Tokyo JapanDepartment of Intensive Care Medicine National Defense Medical College Tokorozawa JapanAbstract Type 2 diabetes mellitus (T2DM) is a major cause of microvascular dysfunction. However, its effect on blood flow patterns during ischemic demand has not been adequately elucidated. In this study, we investigated the hypothesis that microvascular dysfunction in patients with T2DM manifests as brachial reactive hyperemia (BRH), defined as the ratio of peak blood flow velocities in a brachial artery before and after forearm cuff occlusion. The study enrolled 943 subjects (men, n = 152 [T2DM] and n = 371 [non‐T2DM]; women, n = 107 [T2DM] and n = 313 [non‐T2DM], respectively) with no history of cardiovascular disease. Semiautomatic measurements were obtained three times at 1.5‐year intervals to confirm the reproducibility of factors involved in BRH for each sex. An age‐adjusted mixed model demonstrated attenuated BRH in the presence of T2DM in both men (p = 0.022) and women (p = 0.031) throughout the study period. Post hoc analysis showed that the estimated BRH was significantly attenuated in patients with T2DM regardless of sex, except at baseline in women. In multivariate regression analysis, T2DM was a negative predictor of BRH at every measurement in men. For women, BRH was more strongly associated with alcohol consumption. Repeated measurements analysis revealed that T2DM was associated with attenuated postocclusion reactive hyperemia.https://doi.org/10.14814/phy2.15786clinical studydiabetes mellitusendothelial functionhyperglycemiareactive hyperemia |
| spellingShingle | Nobuyuki Masaki Takeshi Adachi Hirofumi Tomiyama Takahide Kohro Toru Suzuki Tomoko Ishizu Shinichiro Ueda Tsutomu Yamazaki Tomoo Furumoto Kazuomi Kario Teruo Inoue Shinji Koba Yasuhiko Takemoto Takuzo Hano Masataka Sata Yutaka Ishibashi Koichi Node Koji Maemura Yusuke Ohya Taiji Furukawa Hiroshi Ito Yukihito Higashi Akira Yamashina Bonpei Takase Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study Physiological Reports clinical study diabetes mellitus endothelial function hyperglycemia reactive hyperemia |
| title | Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study |
| title_full | Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study |
| title_fullStr | Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study |
| title_full_unstemmed | Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study |
| title_short | Reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements: The FMD‐J B study |
| title_sort | reduced reactive hyperemia of the brachial artery in diabetic patients assessed by repeated measurements the fmd j b study |
| topic | clinical study diabetes mellitus endothelial function hyperglycemia reactive hyperemia |
| url | https://doi.org/10.14814/phy2.15786 |
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