The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats
Background & aim: Diabetes is a metabolic disorder characterized by hyperglycemia. Hyperglycemia through enzymatic and non-enzymatic processes causes induction of spontaneous oxidation of glucose and, by stimulating the production of active oxygen and nitrogen components, leading to oxidative st...
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| Format: | Article |
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Yasuj University Of Medical Sciences
2016-11-01
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| Series: | Armaghane Danesh Bimonthly Journal |
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| Online Access: | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-767-1&slc_lang=en&sid=1 |
| _version_ | 1811181271971266560 |
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| author | Z Karampour Qipchaq R Heidari SM Abtahi Froushani F Farokhi |
| author_facet | Z Karampour Qipchaq R Heidari SM Abtahi Froushani F Farokhi |
| author_sort | Z Karampour Qipchaq |
| collection | DOAJ |
| description | Background & aim: Diabetes is a metabolic disorder characterized by hyperglycemia. Hyperglycemia through enzymatic and non-enzymatic processes causes induction of spontaneous oxidation of glucose and, by stimulating the production of active oxygen and nitrogen components, leading to oxidative stress. Thus, according to the antioxidant effects of atorvastatin and zinc oxide, the aim of this study was to investigate the combined effect of atorvastatin and zinc oxide on oxidative stress and antioxidants in diabetic rats.
Methods: In the present experimental study, 50 female Wistar rats were selected randomly and divided into five groups of 10 (n=10) including : normal control (NC), diabetic control (DC), diabetic rats treated with, atorvastatin (20mg/kg daily-orally) (DA), zinc oxide (30mg/kg daily-rally) (DZ) and combination of each drug in half-dose (daily-orally) (DAZ), were each treated separately. Diabetic rats were induced by injection of 60 mg per kg of body weight of streptozotocin (STZ) intraperitoneally.All treatments were dissolved in distilled water for four weeks. After completion of treatment (forth week), weight and blood sugar were measured and then compared with data measured on weight and blood sugar in the weeks before the start and second week of the study. The lipid peroxidation level (MDA), the activity of catalase (CAT) and total antioxidant capacity (TAC) as an indicator of oxidative stress were measured in the hippocampus. Data were analyzed using ANOVA and Tukey tests.
Results: Zinc oxide and atorvastatin alone rather than decrease blood sugar, reduced the complications of diabetes, including oxidative damage and combination of both reduced levels of diabetic complications led to the significant decrease in blood glucose levels and inhibiting the animal lose weight.
Conclusion: It seemed that the combination of atorvastatin and zinc oxide have synergistic benefits to control blood sugar levels and oxidative stress, and also resulting in control of diabetes. |
| first_indexed | 2024-04-11T09:15:45Z |
| format | Article |
| id | doaj.art-2bb776b7fb104c6c9391bb69cdf29e6b |
| institution | Directory Open Access Journal |
| issn | 1728-6514 1728-6506 |
| language | fas |
| last_indexed | 2024-04-11T09:15:45Z |
| publishDate | 2016-11-01 |
| publisher | Yasuj University Of Medical Sciences |
| record_format | Article |
| series | Armaghane Danesh Bimonthly Journal |
| spelling | doaj.art-2bb776b7fb104c6c9391bb69cdf29e6b2022-12-22T04:32:21ZfasYasuj University Of Medical SciencesArmaghane Danesh Bimonthly Journal1728-65141728-65062016-11-01218730745The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic RatsZ Karampour Qipchaq0R Heidari1SM Abtahi Froushani2F Farokhi3 Department of Biochemistry, University of Urmia, Urmia, Iran, Department of Biochemistry, University of Urmia, Urmia, Iran, Department of Microbiology, University of Urmia, Urmia, Iran, Department of Tissue and Anatomy, University of Urmia, Urmia, Iran Background & aim: Diabetes is a metabolic disorder characterized by hyperglycemia. Hyperglycemia through enzymatic and non-enzymatic processes causes induction of spontaneous oxidation of glucose and, by stimulating the production of active oxygen and nitrogen components, leading to oxidative stress. Thus, according to the antioxidant effects of atorvastatin and zinc oxide, the aim of this study was to investigate the combined effect of atorvastatin and zinc oxide on oxidative stress and antioxidants in diabetic rats. Methods: In the present experimental study, 50 female Wistar rats were selected randomly and divided into five groups of 10 (n=10) including : normal control (NC), diabetic control (DC), diabetic rats treated with, atorvastatin (20mg/kg daily-orally) (DA), zinc oxide (30mg/kg daily-rally) (DZ) and combination of each drug in half-dose (daily-orally) (DAZ), were each treated separately. Diabetic rats were induced by injection of 60 mg per kg of body weight of streptozotocin (STZ) intraperitoneally.All treatments were dissolved in distilled water for four weeks. After completion of treatment (forth week), weight and blood sugar were measured and then compared with data measured on weight and blood sugar in the weeks before the start and second week of the study. The lipid peroxidation level (MDA), the activity of catalase (CAT) and total antioxidant capacity (TAC) as an indicator of oxidative stress were measured in the hippocampus. Data were analyzed using ANOVA and Tukey tests. Results: Zinc oxide and atorvastatin alone rather than decrease blood sugar, reduced the complications of diabetes, including oxidative damage and combination of both reduced levels of diabetic complications led to the significant decrease in blood glucose levels and inhibiting the animal lose weight. Conclusion: It seemed that the combination of atorvastatin and zinc oxide have synergistic benefits to control blood sugar levels and oxidative stress, and also resulting in control of diabetes.http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-767-1&slc_lang=en&sid=1diabetes atorvastatin zinc oxide oxidative stress the hippocampus of rats |
| spellingShingle | Z Karampour Qipchaq R Heidari SM Abtahi Froushani F Farokhi The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats Armaghane Danesh Bimonthly Journal diabetes atorvastatin zinc oxide oxidative stress the hippocampus of rats |
| title | The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats |
| title_full | The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats |
| title_fullStr | The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats |
| title_full_unstemmed | The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats |
| title_short | The Effects of Combined Atorvastatin and Zinc Oxide on Some Markers of Oxidative Stress in the Hippocampus in Streptozotocin-induced Diabetic Rats |
| title_sort | effects of combined atorvastatin and zinc oxide on some markers of oxidative stress in the hippocampus in streptozotocin induced diabetic rats |
| topic | diabetes atorvastatin zinc oxide oxidative stress the hippocampus of rats |
| url | http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-767-1&slc_lang=en&sid=1 |
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