Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis
Objective: The aim of this study was to evaluate the prognostic value of coronary artery disease (CAD) detected by coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. Methods: A total of 331 patie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024042932 |
| _version_ | 1827293908088913920 |
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| author | Zengfa Huang Tao Li Shan Zhang Bei Jiang Mei Li Beibei Cao Hongfeng Zhang Zhiqiang Zhou Zheng Huang Xiang Wang |
| author_facet | Zengfa Huang Tao Li Shan Zhang Bei Jiang Mei Li Beibei Cao Hongfeng Zhang Zhiqiang Zhou Zheng Huang Xiang Wang |
| author_sort | Zengfa Huang |
| collection | DOAJ |
| description | Objective: The aim of this study was to evaluate the prognostic value of coronary artery disease (CAD) detected by coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. Methods: A total of 331 patients who previously had cancer and underwent coronary CTA from January 2015 to December 2019 were included. Multivariate Cox proportional hazards regression analysis and propensity-score matching analysis were performed. The primary endpoint was all-cause of mortality. Results: In total, 125 with CAD and 206 with no CAD during a median follow-up of 3.3 years were included in this study. After PSM, age (HR, 1.040; 95%CI, 1.001–1.081; p = 0.014) and CAD (HR, 2.164; 95%CI, 1.057–4.430; p = 0.035) remained significant factors for all-cause mortality. Conclusion: CAD evaluated by coronary CTA was found to be at higher risk for all-cause mortality in cancer patients. Due to the retrospective design and lack of information on some medical history and treatments, especially immune checkpoint inhibitors, a large-scale prospective study is needed to further determine the prognostic value of coronary CTA in cancer patients. |
| first_indexed | 2024-04-24T13:47:58Z |
| format | Article |
| id | doaj.art-2bb870895e714b3a8d22d2dcd1dd8093 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:47:58Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-2bb870895e714b3a8d22d2dcd1dd80932024-04-04T05:07:05ZengElsevierHeliyon2405-84402024-03-01106e28262Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysisZengfa Huang0Tao Li1Shan Zhang2Bei Jiang3Mei Li4Beibei Cao5Hongfeng Zhang6Zhiqiang Zhou7Zheng Huang8Xiang Wang9Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaDepartment of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaDepartment of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaDepartment of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaDepartment of Community Health, Wuhan Hanyang Center For Disease Prevention and Control, Wuhan, 430050, ChinaDepartment of Community Health, Wuhan Hanyang Center For Disease Prevention and Control, Wuhan, 430050, ChinaDepartment of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, ChinaDepartment of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Corresponding author. Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Qiaokou, Wuhan, Hubei, 430030, China.Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China; Corresponding author. Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, Hubei, 430014, China.Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China; Corresponding author. Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, 26 Shengli Avenue, Jiangan, Wuhan, Hubei, 430014, China.Objective: The aim of this study was to evaluate the prognostic value of coronary artery disease (CAD) detected by coronary computed tomography angiography (CTA) to predict the risk of all-cause mortality in cancer patients in a propensity score matching (PSM) analysis. Methods: A total of 331 patients who previously had cancer and underwent coronary CTA from January 2015 to December 2019 were included. Multivariate Cox proportional hazards regression analysis and propensity-score matching analysis were performed. The primary endpoint was all-cause of mortality. Results: In total, 125 with CAD and 206 with no CAD during a median follow-up of 3.3 years were included in this study. After PSM, age (HR, 1.040; 95%CI, 1.001–1.081; p = 0.014) and CAD (HR, 2.164; 95%CI, 1.057–4.430; p = 0.035) remained significant factors for all-cause mortality. Conclusion: CAD evaluated by coronary CTA was found to be at higher risk for all-cause mortality in cancer patients. Due to the retrospective design and lack of information on some medical history and treatments, especially immune checkpoint inhibitors, a large-scale prospective study is needed to further determine the prognostic value of coronary CTA in cancer patients.http://www.sciencedirect.com/science/article/pii/S2405844024042932Coronary computed tomography angiographyCoronary artery diseasePrognosisCancerPropensity score matching |
| spellingShingle | Zengfa Huang Tao Li Shan Zhang Bei Jiang Mei Li Beibei Cao Hongfeng Zhang Zhiqiang Zhou Zheng Huang Xiang Wang Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis Heliyon Coronary computed tomography angiography Coronary artery disease Prognosis Cancer Propensity score matching |
| title | Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis |
| title_full | Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis |
| title_fullStr | Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis |
| title_full_unstemmed | Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis |
| title_short | Association between coronary artery disease and clinical outcome in cancer patients: A propensity score matching analysis |
| title_sort | association between coronary artery disease and clinical outcome in cancer patients a propensity score matching analysis |
| topic | Coronary computed tomography angiography Coronary artery disease Prognosis Cancer Propensity score matching |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024042932 |
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