Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become inc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1070514/full |
| _version_ | 1797988326736658432 |
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| author | Ryan S. Alden Mohammad Zahid Kamran Bassel A. Bashjawish Brittany A. Simone |
| author_facet | Ryan S. Alden Mohammad Zahid Kamran Bassel A. Bashjawish Brittany A. Simone |
| author_sort | Ryan S. Alden |
| collection | DOAJ |
| description | Mounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become increasingly popular in combination with radiotherapy to overcome radioresistance. Over the past year, a focus on glutamine metabolism in the setting of cancer therapy has emerged. In this mini-review, we discuss several important ways (DNA damage repair, oxidative stress, epigenetic modification and immune modulation) glutamine metabolism drives cancer growth and progression, and present data that inhibition of glutamine utilization can lead to radiosensitization in preclinical models. Future research is needed in the clinical realm to determine whether glutamine antagonism is a feasible synergistic therapy that can be combined with radiotherapy. |
| first_indexed | 2024-04-11T08:02:23Z |
| format | Article |
| id | doaj.art-2bb8b076dbd54779b07e58f8c60af15a |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T08:02:23Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2bb8b076dbd54779b07e58f8c60af15a2022-12-22T04:35:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10705141070514Glutamine metabolism and radiosensitivity: Beyond the Warburg effectRyan S. AldenMohammad Zahid KamranBassel A. BashjawishBrittany A. SimoneMounting data suggest that cancer cell metabolism can be utilized therapeutically to halt cell proliferation, metastasis and disease progression. Radiation therapy is a critical component of cancer treatment in curative and palliative settings. The use of metabolism-based therapeutics has become increasingly popular in combination with radiotherapy to overcome radioresistance. Over the past year, a focus on glutamine metabolism in the setting of cancer therapy has emerged. In this mini-review, we discuss several important ways (DNA damage repair, oxidative stress, epigenetic modification and immune modulation) glutamine metabolism drives cancer growth and progression, and present data that inhibition of glutamine utilization can lead to radiosensitization in preclinical models. Future research is needed in the clinical realm to determine whether glutamine antagonism is a feasible synergistic therapy that can be combined with radiotherapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.1070514/fullcancerglutamine (Gln)radiationmetabolismradiosensitivitytelaglenastat |
| spellingShingle | Ryan S. Alden Mohammad Zahid Kamran Bassel A. Bashjawish Brittany A. Simone Glutamine metabolism and radiosensitivity: Beyond the Warburg effect Frontiers in Oncology cancer glutamine (Gln) radiation metabolism radiosensitivity telaglenastat |
| title | Glutamine metabolism and radiosensitivity: Beyond the Warburg effect |
| title_full | Glutamine metabolism and radiosensitivity: Beyond the Warburg effect |
| title_fullStr | Glutamine metabolism and radiosensitivity: Beyond the Warburg effect |
| title_full_unstemmed | Glutamine metabolism and radiosensitivity: Beyond the Warburg effect |
| title_short | Glutamine metabolism and radiosensitivity: Beyond the Warburg effect |
| title_sort | glutamine metabolism and radiosensitivity beyond the warburg effect |
| topic | cancer glutamine (Gln) radiation metabolism radiosensitivity telaglenastat |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1070514/full |
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