Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up
The objective of this study is to report the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in three patients with medication-refractory Tourette syndrome (TS) and over 3-month follow-up. A review of literature on the use of rTMS for the treatment of TS is also presente...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Indian Journal of Psychological Medicine |
| Subjects: | |
| Online Access: | http://www.ijpm.info/article.asp?issn=0253-7176;year=2018;volume=40;issue=5;spage=482;epage=486;aulast=Singh |
| _version_ | 1819145177733791744 |
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| author | Swarndeep Singh Saurabh Kumar Nand Kumar Rohit Verma |
| author_facet | Swarndeep Singh Saurabh Kumar Nand Kumar Rohit Verma |
| author_sort | Swarndeep Singh |
| collection | DOAJ |
| description | The objective of this study is to report the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in three patients with medication-refractory Tourette syndrome (TS) and over 3-month follow-up. A review of literature on the use of rTMS for the treatment of TS is also presented. Three patients with severe, medication-refractory TS and comorbid obsessive-compulsive disorder (OCD) in two of them, received an open-label trial of rTMS at 1 Hz frequency for 4-week duration. The first two cases of TS-OCD showed, on average, around 57% improvement in Yale Global Tic Severity Scale (YGTSS) scores (65% and 50%) and 45% improvement in Yale-Brown Obsessive-compulsive Scale (Y-BOCS) scores; however, the third case of pure-TS showed marginal improvement of 10% only. The improvement in TS-OCD patients with rTMS treatment was maintained at the end of 3-month follow-up, with an average reduction of about 49% (58% and 40%) and 36% observed in YGTSS and Y-BOCS scores, respectively. The present study supports the use of low-frequency rTMS to improve tics and OCD symptoms in patients with severe, medication-refractory TS-OCD. Further, the beneficial effects of rTMS treatment were maintained substantially over 3-month follow-up period. |
| first_indexed | 2024-12-22T12:53:53Z |
| format | Article |
| id | doaj.art-2bb9f8cde96a4e83ac57cd21ca5646fa |
| institution | Directory Open Access Journal |
| issn | 0253-7176 |
| language | English |
| last_indexed | 2024-12-22T12:53:53Z |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Psychological Medicine |
| spelling | doaj.art-2bb9f8cde96a4e83ac57cd21ca5646fa2022-12-21T18:25:10ZengSAGE PublishingIndian Journal of Psychological Medicine0253-71762018-01-0140548248610.4103/IJPSYM.IJPSYM_332_17Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-upSwarndeep SinghSaurabh KumarNand KumarRohit VermaThe objective of this study is to report the effects of low-frequency repetitive transcranial magnetic stimulation (rTMS) in three patients with medication-refractory Tourette syndrome (TS) and over 3-month follow-up. A review of literature on the use of rTMS for the treatment of TS is also presented. Three patients with severe, medication-refractory TS and comorbid obsessive-compulsive disorder (OCD) in two of them, received an open-label trial of rTMS at 1 Hz frequency for 4-week duration. The first two cases of TS-OCD showed, on average, around 57% improvement in Yale Global Tic Severity Scale (YGTSS) scores (65% and 50%) and 45% improvement in Yale-Brown Obsessive-compulsive Scale (Y-BOCS) scores; however, the third case of pure-TS showed marginal improvement of 10% only. The improvement in TS-OCD patients with rTMS treatment was maintained at the end of 3-month follow-up, with an average reduction of about 49% (58% and 40%) and 36% observed in YGTSS and Y-BOCS scores, respectively. The present study supports the use of low-frequency rTMS to improve tics and OCD symptoms in patients with severe, medication-refractory TS-OCD. Further, the beneficial effects of rTMS treatment were maintained substantially over 3-month follow-up period.http://www.ijpm.info/article.asp?issn=0253-7176;year=2018;volume=40;issue=5;spage=482;epage=486;aulast=SinghObsessive-compulsive disorderrepetitive transcranial magnetic stimulationTourette syndrome |
| spellingShingle | Swarndeep Singh Saurabh Kumar Nand Kumar Rohit Verma Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up Indian Journal of Psychological Medicine Obsessive-compulsive disorder repetitive transcranial magnetic stimulation Tourette syndrome |
| title | Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up |
| title_full | Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up |
| title_fullStr | Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up |
| title_full_unstemmed | Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up |
| title_short | Low-frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome: a naturalistic study with 3 months of follow-up |
| title_sort | low frequency repetitive transcranial magnetic stimulation for treatment of tourette syndrome a naturalistic study with 3 months of follow up |
| topic | Obsessive-compulsive disorder repetitive transcranial magnetic stimulation Tourette syndrome |
| url | http://www.ijpm.info/article.asp?issn=0253-7176;year=2018;volume=40;issue=5;spage=482;epage=486;aulast=Singh |
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