Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis
BackgroundGut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully cla...
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| Format: | Article |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1119875/full |
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| author | Xing Yang Xing Yang Huanzhuo Mai Huanzhuo Mai Jie Zhou Jie Zhou Zhuoxin Li Zhuoxin Li Qing Wang Qing Wang Liuyan Lan Liuyan Lan Fang Lu Fang Lu Xiping Yang Xiping Yang Baodong Guo Baodong Guo Li Ye Li Ye Ping Cui Ping Cui Ping Cui Hao Liang Hao Liang Hao Liang Hao Liang Jiegang Huang Jiegang Huang Jiegang Huang |
| author_facet | Xing Yang Xing Yang Huanzhuo Mai Huanzhuo Mai Jie Zhou Jie Zhou Zhuoxin Li Zhuoxin Li Qing Wang Qing Wang Liuyan Lan Liuyan Lan Fang Lu Fang Lu Xiping Yang Xiping Yang Baodong Guo Baodong Guo Li Ye Li Ye Ping Cui Ping Cui Ping Cui Hao Liang Hao Liang Hao Liang Hao Liang Jiegang Huang Jiegang Huang Jiegang Huang |
| author_sort | Xing Yang |
| collection | DOAJ |
| description | BackgroundGut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.MethodsPubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.ResultsOf the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, n = 546; HCV, n = 86; HEV, n = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including Butyricimonas, Escherichia-Shigella, Lactobacillus, and Veillonella were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.ConclusionsThis study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis. |
| first_indexed | 2024-03-13T07:16:49Z |
| format | Article |
| id | doaj.art-2bbbb50423ac465bba4d2cd972a8ddde |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-13T07:16:49Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-2bbbb50423ac465bba4d2cd972a8ddde2023-06-05T05:06:57ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-06-011310.3389/fcimb.2023.11198751119875Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitisXing Yang0Xing Yang1Huanzhuo Mai2Huanzhuo Mai3Jie Zhou4Jie Zhou5Zhuoxin Li6Zhuoxin Li7Qing Wang8Qing Wang9Liuyan Lan10Liuyan Lan11Fang Lu12Fang Lu13Xiping Yang14Xiping Yang15Baodong Guo16Baodong Guo17Li Ye18Li Ye19Ping Cui20Ping Cui21Ping Cui22Hao Liang23Hao Liang24Hao Liang25Hao Liang26Jiegang Huang27Jiegang Huang28Jiegang Huang29School of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaLife Science Institute, Guangxi Medical University, Nanning, ChinaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaLife Science Institute, Guangxi Medical University, Nanning, ChinaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry, Guangxi Medical University, Nanning, ChinaSchool of Public Health, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of AIDS Prevention and Treatment, Guangxi Universities Key Laboratory of Prevention and Control of Highly Prevalent Disease, Guangxi Medical University, Nanning, ChinaGuangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, ChinaBackgroundGut microbiota is the largest population of microorganisms and is closely related to health. Many studies have explored changes in gut microbiota in viral hepatitis. However, the correlation between gut microbiota and the occurrence and progression of viral hepatitis has not been fully clarified.MethodsPubMed and BioProject databases were searched for studies about viral hepatitis disease and 16S rRNA gene sequencing of gut microbiota up to January 2023. With bioinformatics analyses, we explored changes in microbial diversity of viral hepatitis, screened out crucial bacteria and microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting risks for the occurrence and progression of viral hepatitis based on ROC analysis.ResultsOf the 1389 records identified, 13 studies met the inclusion criteria, with 950 individuals including 656 patient samples (HBV, n = 546; HCV, n = 86; HEV, n = 24) and 294 healthy controls. Gut microbial diversity is significantly decreased as the infection and progression of viral hepatitis. Alpha diversity and microbiota including Butyricimonas, Escherichia-Shigella, Lactobacillus, and Veillonella were identified as the potential microbial markers for predicting the risk of development of viral hepatitis (AUC>0.7). Microbial functions including tryptophan metabolism, fatty acid biosynthesis, lipopolysaccharide biosynthesis, and lipid metabolism related to the microbial community increased significantly as the development of viral hepatitis.ConclusionsThis study demonstrated comprehensively the gut microbiota characteristics in viral hepatitis, screened out crucial microbial functions related to viral hepatitis, and identified the potential microbial markers for predicting the risk of viral hepatitis.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1119875/fullgut microbiota16s ribosomal RNA gene amplicon sequencingviral hepatitisliver diseasemicrobial markers |
| spellingShingle | Xing Yang Xing Yang Huanzhuo Mai Huanzhuo Mai Jie Zhou Jie Zhou Zhuoxin Li Zhuoxin Li Qing Wang Qing Wang Liuyan Lan Liuyan Lan Fang Lu Fang Lu Xiping Yang Xiping Yang Baodong Guo Baodong Guo Li Ye Li Ye Ping Cui Ping Cui Ping Cui Hao Liang Hao Liang Hao Liang Hao Liang Jiegang Huang Jiegang Huang Jiegang Huang Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis Frontiers in Cellular and Infection Microbiology gut microbiota 16s ribosomal RNA gene amplicon sequencing viral hepatitis liver disease microbial markers |
| title | Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| title_full | Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| title_fullStr | Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| title_full_unstemmed | Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| title_short | Alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| title_sort | alterations of the gut microbiota associated with the occurrence and progression of viral hepatitis |
| topic | gut microbiota 16s ribosomal RNA gene amplicon sequencing viral hepatitis liver disease microbial markers |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1119875/full |
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