Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism
Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presyna...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00136/full |
| _version_ | 1819075146420322304 |
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| author | Ben eAviner Gideon eGradwohl Merav eMor Aviner Shiri eLevy Yoram eGrossman |
| author_facet | Ben eAviner Gideon eGradwohl Merav eMor Aviner Shiri eLevy Yoram eGrossman |
| author_sort | Ben eAviner |
| collection | DOAJ |
| description | Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca2+ currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca2+ channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in CaV1.2 and depressed it in CaV3.2 channels. Pressure application also affected the channels' kinetics, such as ƮRise, ƮDecay. Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms. |
| first_indexed | 2024-12-21T18:20:46Z |
| format | Article |
| id | doaj.art-2bbc38e02f634e6a856b1fe222317d09 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-21T18:20:46Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-2bbc38e02f634e6a856b1fe222317d092022-12-21T18:54:33ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-05-01810.3389/fncel.2014.0013668137Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanismBen eAviner0Gideon eGradwohl1Merav eMor Aviner2Shiri eLevy3Yoram eGrossman4Ben Gurion University of the NegevJerusalem College of TechnologyBen Gurion University of the NegevBen Gurion University of the NegevBen Gurion University of the NegevProfessional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca2+ currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca2+ channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in CaV1.2 and depressed it in CaV3.2 channels. Pressure application also affected the channels' kinetics, such as ƮRise, ƮDecay. Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00136/fullHigh Pressure Neurological SyndromeSynaptic Transmissionconformational changehigh pressureHyperbaric helium pressurevoltage dependency |
| spellingShingle | Ben eAviner Gideon eGradwohl Merav eMor Aviner Shiri eLevy Yoram eGrossman Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism Frontiers in Cellular Neuroscience High Pressure Neurological Syndrome Synaptic Transmission conformational change high pressure Hyperbaric helium pressure voltage dependency |
| title | Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism |
| title_full | Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism |
| title_fullStr | Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism |
| title_full_unstemmed | Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism |
| title_short | Selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure - a suggested HPNS partial mechanism |
| title_sort | selective modulation of cellular voltage dependent calcium channels by hyperbaric pressure a suggested hpns partial mechanism |
| topic | High Pressure Neurological Syndrome Synaptic Transmission conformational change high pressure Hyperbaric helium pressure voltage dependency |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00136/full |
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