Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway

Destruxin B Suppresses Drug-Resistant Colon Tumorigenesis and Stemness Is Associated with the Upregulation of miR-214 and Downregulation of mTOR/β-Catenin Pathway

Background: Drug resistance represents a major challenge for treating patients with colon cancer. Accumulating evidence suggests that Insulin-like growth factor (IGF)-associated signaling promotes colon tumorigenesis and cancer stemness. Therefore, the identification of agents, which can disrupt can...

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Bibliographic Details
Main Authors: Szu-Yuan Wu, Yan-Jiun Huang, Yew-Min Tzeng, Chi-Ying F. Huang, Michael Hsiao, Alexander T.H. Wu, Tse-Hung Huang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
colon cancer
destruxin B
cancer stem-like cells
5-FU resistance
mTOR/β-catenin signaling and miR-214
Online Access:http://www.mdpi.com/2072-6694/10/10/353

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