A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex
<p>Abstract</p> <p>Background</p> <p>In <it>Drosophila melanogaster</it>, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence...
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| Format: | Article |
| Language: | English |
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BMC
2010-03-01
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| Series: | BMC Genomics |
| Online Access: | http://www.biomedcentral.com/1471-2164/11/169 |
| _version_ | 1811281763536732160 |
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| author | Aldecoa Rodrigo Arnau Vicente Gallach Miguel Marín Ignacio |
| author_facet | Aldecoa Rodrigo Arnau Vicente Gallach Miguel Marín Ignacio |
| author_sort | Aldecoa Rodrigo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>In <it>Drosophila melanogaster</it>, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found.</p> <p>Results</p> <p>In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the <it>D. melanogaster </it>X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate that the same sequences may be involved in dosage compensation in other <it>Drosophila </it>species.</p> <p>Conclusions</p> <p>These results offer an explanation for the wild-type binding of the DCC along the <it>Drosophila </it>X chromosome, contribute to delineate the forces leading to the establishment of dosage compensation and suggest new experimental approaches to understand the precise biochemical features of the dosage compensation system.</p> |
| first_indexed | 2024-04-13T01:39:29Z |
| format | Article |
| id | doaj.art-2bbd951162fe40399c83759eac0416c3 |
| institution | Directory Open Access Journal |
| issn | 1471-2164 |
| language | English |
| last_indexed | 2024-04-13T01:39:29Z |
| publishDate | 2010-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genomics |
| spelling | doaj.art-2bbd951162fe40399c83759eac0416c32022-12-22T03:08:14ZengBMCBMC Genomics1471-21642010-03-0111116910.1186/1471-2164-11-169A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complexAldecoa RodrigoArnau VicenteGallach MiguelMarín Ignacio<p>Abstract</p> <p>Background</p> <p>In <it>Drosophila melanogaster</it>, dosage compensation is mediated by the action of the dosage compensation complex (DCC). How the DCC recognizes the fly X chromosome is still poorly understood. Characteristic sequence signatures at all DCC binding sites have not hitherto been found.</p> <p>Results</p> <p>In this study, we compare the known binding sites of the DCC with oligonucleotide profiles that measure the specificity of the sequences of the <it>D. melanogaster </it>X chromosome. We show that the X chromosome regions bound by the DCC are enriched for a particular type of short, repetitive sequences. Their distribution suggests that these sequences contribute to chromosome recognition, the generation of DCC binding sites and/or the local spreading of the complex. Comparative data indicate that the same sequences may be involved in dosage compensation in other <it>Drosophila </it>species.</p> <p>Conclusions</p> <p>These results offer an explanation for the wild-type binding of the DCC along the <it>Drosophila </it>X chromosome, contribute to delineate the forces leading to the establishment of dosage compensation and suggest new experimental approaches to understand the precise biochemical features of the dosage compensation system.</p>http://www.biomedcentral.com/1471-2164/11/169 |
| spellingShingle | Aldecoa Rodrigo Arnau Vicente Gallach Miguel Marín Ignacio A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex BMC Genomics |
| title | A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex |
| title_full | A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex |
| title_fullStr | A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex |
| title_full_unstemmed | A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex |
| title_short | A sequence motif enriched in regions bound by the <it>Drosophila </it>dosage compensation complex |
| title_sort | sequence motif enriched in regions bound by the it drosophila it dosage compensation complex |
| url | http://www.biomedcentral.com/1471-2164/11/169 |
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