Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects

Analysis of miRNA rare variants in amyotrophic lateral sclerosis and in silico prediction of their biological effects

Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and/or lower motor neurons and characterized by complex etiology. Familial cases show high genetic heterogeneity and sporadic cases (90%) are associated with several genetic and environmental risk factors....

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Main Authors: Alberto Brusati, Antonia Ratti, Viviana Pensato, Silvia Peverelli, Davide Gentilini, Eleonora Dalla Bella, Marta Nice Sorce, Megi Meneri, Delia Gagliardi, Stefania Corti, Cinzia Gellera, Giuseppe Lauria Pinter, Nicola Ticozzi, Vincenzo Silani
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Genetics
Subjects:
ALS
miRNA
WGS
rare variants
bioinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.1055313/full

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