Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme
Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fie...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2017-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2017-0100 |
| _version_ | 1797848692719353856 |
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| author | Oberacker Eva Kuehne Andre Nadobny Jacek Zschaeck Sebastian Weihrauch Mirko Waiczies Helmar Ghadjar Pirus Wust Peter Niendorf Thoralf Winter Lukas |
| author_facet | Oberacker Eva Kuehne Andre Nadobny Jacek Zschaeck Sebastian Weihrauch Mirko Waiczies Helmar Ghadjar Pirus Wust Peter Niendorf Thoralf Winter Lukas |
| author_sort | Oberacker Eva |
| collection | DOAJ |
| description | Glioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on electromagnetic field (EMF) simulations and provides realistic applicator designs tailored for simultaneous RF heating and MRI. Our simulations took advantage of target volumes derived from patient data, and our preliminary results suggest that RF power can be focused to both a small tumor area and a large clinical target volume. |
| first_indexed | 2024-04-09T18:32:45Z |
| format | Article |
| id | doaj.art-2bc0dd20ba0741fba8b91eaa7a478450 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-04-09T18:32:45Z |
| publishDate | 2017-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-2bc0dd20ba0741fba8b91eaa7a4784502023-04-11T17:07:14ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042017-09-013247347710.1515/cdbme-2017-0100cdbme-2017-0100Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiformeOberacker Eva0Kuehne Andre1Nadobny Jacek2Zschaeck Sebastian3Weihrauch Mirko4Waiczies Helmar5Ghadjar Pirus6Wust Peter7Niendorf Thoralf8Winter Lukas9Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Centrum for Molecular Medicine in the Helmholtz Association, Robert-Rössle-Str. 10, 13125 Berlin, GermanyMRI.TOOLS GmbH, Berlin, GermanyClinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GermanyClinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GermanyClinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GermanyMRI.TOOLS GmbH, Berlin, GermanyClinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GermanyClinic for Radiation Oncology, Charité Universitätsmedizin, Berlin, GermanyMRI.TOOLS GmbH, Berlin, GermanyBerlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Centrum for Molecular Medicine in the Helmholtz Association, Berlin, GermanyGlioblastoma multiforme is the most frequent and most aggressive malignant brain tumor with de facto no long term curation by the use of current multimodal therapeutic approaches. The efficacy of brachytherapy and enhancing interstitial hyperthermia has been demonstrated. RF heating at ultrahigh fields (B0=7.0T, f=298MHz) has the potential of delivering sufficiently large thermal dosage for hyperthermia of relatively large tumor areas. This work focuses on electromagnetic field (EMF) simulations and provides realistic applicator designs tailored for simultaneous RF heating and MRI. Our simulations took advantage of target volumes derived from patient data, and our preliminary results suggest that RF power can be focused to both a small tumor area and a large clinical target volume.https://doi.org/10.1515/cdbme-2017-0100thermal magnetic resonancerf heatinghyperthermiaglioblastoma multiformerf applicator |
| spellingShingle | Oberacker Eva Kuehne Andre Nadobny Jacek Zschaeck Sebastian Weihrauch Mirko Waiczies Helmar Ghadjar Pirus Wust Peter Niendorf Thoralf Winter Lukas Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme Current Directions in Biomedical Engineering thermal magnetic resonance rf heating hyperthermia glioblastoma multiforme rf applicator |
| title | Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme |
| title_full | Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme |
| title_fullStr | Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme |
| title_full_unstemmed | Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme |
| title_short | Radiofrequency applicator concepts for simultaneous MR imaging and hyperthermia treatment of glioblastoma multiforme |
| title_sort | radiofrequency applicator concepts for simultaneous mr imaging and hyperthermia treatment of glioblastoma multiforme |
| topic | thermal magnetic resonance rf heating hyperthermia glioblastoma multiforme rf applicator |
| url | https://doi.org/10.1515/cdbme-2017-0100 |
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