Non-linear association between composite dietary antioxidant index and depression
BackgroundGrowing evidence has shown that the antioxidant diet is a protective factor against depression. However, the relationship between the Composite Dietary Antioxidant Index (CDAI), an important measure of antioxidant diet, and depression has received little attention. Therefore, we investigat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.988727/full |
| _version_ | 1811342351132524544 |
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| author | Leiyong Zhao Yiyan Sun Renshuang Cao Xueqiang Wu Tianjiao Huang Wei Peng |
| author_facet | Leiyong Zhao Yiyan Sun Renshuang Cao Xueqiang Wu Tianjiao Huang Wei Peng |
| author_sort | Leiyong Zhao |
| collection | DOAJ |
| description | BackgroundGrowing evidence has shown that the antioxidant diet is a protective factor against depression. However, the relationship between the Composite Dietary Antioxidant Index (CDAI), an important measure of antioxidant diet, and depression has received little attention. Therefore, we investigated the relationship between CDAI and depression through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.MethodsThe association between CDAI and depression was investigated using a weighted multiple logistic regression model with subgroup analysis. Non-linear correlations were explored using fitted smoothing curves. And we used a recursive method to figure out the turning point and build a weighted two-piece linear regression model.ResultsIn the multivariate logistic regression model with full adjustment for confounding variables, the ORs (95% CI) for the association between CDAI and depression were 0.83 (0.78, 0.88). Moreover, a non-linear association was found, with 0.16 being the inflection point. Before the inflection point, each unit increase in CDAI was associated with a 30% decrease in the risk of depression. After the inflection point, the risk of depression was found to be reduced by 11% for each unit increase. None of the interactions in all subgroup analyses were statistically significant.ConclusionsOur study highlighted a negative non-linear association between CDAI and depression in a nationally representative sample of US adults. Further clinical and basic research is needed to explore their association better. |
| first_indexed | 2024-04-13T19:09:58Z |
| format | Article |
| id | doaj.art-2bc1f947c3814d789b2089428ce596f3 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T19:09:58Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-2bc1f947c3814d789b2089428ce596f32022-12-22T02:33:52ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.988727988727Non-linear association between composite dietary antioxidant index and depressionLeiyong Zhao0Yiyan Sun1Renshuang Cao2Xueqiang Wu3Tianjiao Huang4Wei Peng5Department of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe First Clinical College of Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of Psychosomatic Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaBackgroundGrowing evidence has shown that the antioxidant diet is a protective factor against depression. However, the relationship between the Composite Dietary Antioxidant Index (CDAI), an important measure of antioxidant diet, and depression has received little attention. Therefore, we investigated the relationship between CDAI and depression through a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018.MethodsThe association between CDAI and depression was investigated using a weighted multiple logistic regression model with subgroup analysis. Non-linear correlations were explored using fitted smoothing curves. And we used a recursive method to figure out the turning point and build a weighted two-piece linear regression model.ResultsIn the multivariate logistic regression model with full adjustment for confounding variables, the ORs (95% CI) for the association between CDAI and depression were 0.83 (0.78, 0.88). Moreover, a non-linear association was found, with 0.16 being the inflection point. Before the inflection point, each unit increase in CDAI was associated with a 30% decrease in the risk of depression. After the inflection point, the risk of depression was found to be reduced by 11% for each unit increase. None of the interactions in all subgroup analyses were statistically significant.ConclusionsOur study highlighted a negative non-linear association between CDAI and depression in a nationally representative sample of US adults. Further clinical and basic research is needed to explore their association better.https://www.frontiersin.org/articles/10.3389/fpubh.2022.988727/fullnon-linearCDAIdepressionNHANEScross-sectional research |
| spellingShingle | Leiyong Zhao Yiyan Sun Renshuang Cao Xueqiang Wu Tianjiao Huang Wei Peng Non-linear association between composite dietary antioxidant index and depression Frontiers in Public Health non-linear CDAI depression NHANES cross-sectional research |
| title | Non-linear association between composite dietary antioxidant index and depression |
| title_full | Non-linear association between composite dietary antioxidant index and depression |
| title_fullStr | Non-linear association between composite dietary antioxidant index and depression |
| title_full_unstemmed | Non-linear association between composite dietary antioxidant index and depression |
| title_short | Non-linear association between composite dietary antioxidant index and depression |
| title_sort | non linear association between composite dietary antioxidant index and depression |
| topic | non-linear CDAI depression NHANES cross-sectional research |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.988727/full |
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