Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review
Stroke is the leading cause of functional disability worldwide, with increasing prevalence in adults. Given the considerable negative impact on patients’ quality of life and the financial burden on their families and society, it is essential to provide stroke survivors with a timely and reliable pro...
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MDPI AG
2023-08-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/15/3/64 |
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| author | Theofanis Dimaras Ermis Merkouris Dimitrios Tsiptsios Foteini Christidi Anastasia Sousanidou Ilias Orgianelis Efthymia Polatidou Iordanis Kamenidis Stella Karatzetzou Aimilios Gkantzios Christos Ntatsis Christos Kokkotis Sofia Retsidou Maria Aristidou Maria Karageorgopoulou Evlampia A. Psatha Nikolaos Aggelousis Konstantinos Vadikolias |
| author_facet | Theofanis Dimaras Ermis Merkouris Dimitrios Tsiptsios Foteini Christidi Anastasia Sousanidou Ilias Orgianelis Efthymia Polatidou Iordanis Kamenidis Stella Karatzetzou Aimilios Gkantzios Christos Ntatsis Christos Kokkotis Sofia Retsidou Maria Aristidou Maria Karageorgopoulou Evlampia A. Psatha Nikolaos Aggelousis Konstantinos Vadikolias |
| author_sort | Theofanis Dimaras |
| collection | DOAJ |
| description | Stroke is the leading cause of functional disability worldwide, with increasing prevalence in adults. Given the considerable negative impact on patients’ quality of life and the financial burden on their families and society, it is essential to provide stroke survivors with a timely and reliable prognosis of stroke recurrence. Leukoaraiosis (LA) is a common neuroimaging feature of cerebral small-vessel disease. By researching the literature of two different databases (MEDLINE and Scopus), the present study aims to review all relevant studies from the last decade, dealing with the clinical utility of pre-existing LA as a prognostic factor for stroke recurrence in stroke survivors. Nineteen full-text articles published in English were identified and included in the present review, with data collected from a total of 34,546 stroke patients. A higher rate of extended LA was strongly associated with stroke recurrence in all stroke subtypes, even after adjustment for clinical risk factors. In particular, patients with ischemic stroke or transient ischemic attack with advanced LA had a significantly higher risk of future ischemic stroke, whereas patients with previous intracerebral hemorrhage and severe LA had a more than 2.5-fold increased risk of recurrent ischemic stroke and a more than 30-fold increased risk of hemorrhagic stroke. Finally, in patients receiving anticoagulant treatment for AF, the presence of LA was associated with an increased risk of recurrent ischemic stroke and intracranial hemorrhage. Because of this valuable predictive information, evaluating LA could significantly expand our knowledge of stroke patients and thereby improve overall stroke care. |
| first_indexed | 2024-03-10T22:21:04Z |
| format | Article |
| id | doaj.art-2bc32a3c96a64142a8f45abc4c61c8a5 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T22:21:04Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-2bc32a3c96a64142a8f45abc4c61c8a52023-11-19T12:15:54ZengMDPI AGNeurology International2035-83772023-08-01153994101310.3390/neurolint15030064Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic ReviewTheofanis Dimaras0Ermis Merkouris1Dimitrios Tsiptsios2Foteini Christidi3Anastasia Sousanidou4Ilias Orgianelis5Efthymia Polatidou6Iordanis Kamenidis7Stella Karatzetzou8Aimilios Gkantzios9Christos Ntatsis10Christos Kokkotis11Sofia Retsidou12Maria Aristidou13Maria Karageorgopoulou14Evlampia A. Psatha15Nikolaos Aggelousis16Konstantinos Vadikolias17Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceStroke is the leading cause of functional disability worldwide, with increasing prevalence in adults. Given the considerable negative impact on patients’ quality of life and the financial burden on their families and society, it is essential to provide stroke survivors with a timely and reliable prognosis of stroke recurrence. Leukoaraiosis (LA) is a common neuroimaging feature of cerebral small-vessel disease. By researching the literature of two different databases (MEDLINE and Scopus), the present study aims to review all relevant studies from the last decade, dealing with the clinical utility of pre-existing LA as a prognostic factor for stroke recurrence in stroke survivors. Nineteen full-text articles published in English were identified and included in the present review, with data collected from a total of 34,546 stroke patients. A higher rate of extended LA was strongly associated with stroke recurrence in all stroke subtypes, even after adjustment for clinical risk factors. In particular, patients with ischemic stroke or transient ischemic attack with advanced LA had a significantly higher risk of future ischemic stroke, whereas patients with previous intracerebral hemorrhage and severe LA had a more than 2.5-fold increased risk of recurrent ischemic stroke and a more than 30-fold increased risk of hemorrhagic stroke. Finally, in patients receiving anticoagulant treatment for AF, the presence of LA was associated with an increased risk of recurrent ischemic stroke and intracranial hemorrhage. Because of this valuable predictive information, evaluating LA could significantly expand our knowledge of stroke patients and thereby improve overall stroke care.https://www.mdpi.com/2035-8377/15/3/64leukoaraiosiswhite matter hyperintensitiesstrokestroke recurrenceprognosis |
| spellingShingle | Theofanis Dimaras Ermis Merkouris Dimitrios Tsiptsios Foteini Christidi Anastasia Sousanidou Ilias Orgianelis Efthymia Polatidou Iordanis Kamenidis Stella Karatzetzou Aimilios Gkantzios Christos Ntatsis Christos Kokkotis Sofia Retsidou Maria Aristidou Maria Karageorgopoulou Evlampia A. Psatha Nikolaos Aggelousis Konstantinos Vadikolias Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review Neurology International leukoaraiosis white matter hyperintensities stroke stroke recurrence prognosis |
| title | Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review |
| title_full | Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review |
| title_fullStr | Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review |
| title_full_unstemmed | Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review |
| title_short | Leukoaraiosis as a Promising Biomarker of Stroke Recurrence among Stroke Survivors: A Systematic Review |
| title_sort | leukoaraiosis as a promising biomarker of stroke recurrence among stroke survivors a systematic review |
| topic | leukoaraiosis white matter hyperintensities stroke stroke recurrence prognosis |
| url | https://www.mdpi.com/2035-8377/15/3/64 |
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