Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children
<p>Abstract</p> <p>Background</p> <p>Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility o...
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| Format: | Article |
| Language: | English |
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BMC
2007-07-01
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| Series: | BMC Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2156/8/51 |
| _version_ | 1811252492476874752 |
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| author | Bartoshuk Linda M Ring Susan M Day Ian NM Heron Jon Timpson Nicholas J Horwood Jeremy Emmett Pauline Davey-Smith George |
| author_facet | Bartoshuk Linda M Ring Susan M Day Ian NM Heron Jon Timpson Nicholas J Horwood Jeremy Emmett Pauline Davey-Smith George |
| author_sort | Bartoshuk Linda M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to examine the relationships between bitter tasting ability and variation at the <it>TAS2R38 </it>locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability.</p> <p>Results</p> <p>In a large sample of children from the Avon Longitudinal Study of Parents and Children, we confirmed an association between bitter compound tasting ability and <it>TAS2R38 </it>variation and found evidence of a genetic association with intermediate tasting ability. Antisocial behaviour, social class and depression showed no consistent relationship with the distribution of taste test scores.</p> <p>Conclusion</p> <p>Factors which could influence a child's chosen taste score, extra to taste receptor variation, appeared not to show relationships with test score. Observed spread in the distribution of the taste test scores <it>within </it>hypothesised taster groups, is likely to be, or at least in part, due to physiological differentiation regulated by other genetic contributors. Results confirm relationships between genetic variation and bitter compound tasting ability in a large sample, and suggest that <it>TAS2R38 </it>variation may also be associated with intermediate tasting ability.</p> |
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| format | Article |
| id | doaj.art-2bc33f1ceb97402189c165e0ea828837 |
| institution | Directory Open Access Journal |
| issn | 1471-2156 |
| language | English |
| last_indexed | 2024-04-12T16:35:31Z |
| publishDate | 2007-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Genetics |
| spelling | doaj.art-2bc33f1ceb97402189c165e0ea8288372022-12-22T03:25:00ZengBMCBMC Genetics1471-21562007-07-01815110.1186/1471-2156-8-51Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and ChildrenBartoshuk Linda MRing Susan MDay Ian NMHeron JonTimpson Nicholas JHorwood JeremyEmmett PaulineDavey-Smith George<p>Abstract</p> <p>Background</p> <p>Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to examine the relationships between bitter tasting ability and variation at the <it>TAS2R38 </it>locus and to assess the role of psychosocial factors in explaining residual, within group, variation in tasting ability.</p> <p>Results</p> <p>In a large sample of children from the Avon Longitudinal Study of Parents and Children, we confirmed an association between bitter compound tasting ability and <it>TAS2R38 </it>variation and found evidence of a genetic association with intermediate tasting ability. Antisocial behaviour, social class and depression showed no consistent relationship with the distribution of taste test scores.</p> <p>Conclusion</p> <p>Factors which could influence a child's chosen taste score, extra to taste receptor variation, appeared not to show relationships with test score. Observed spread in the distribution of the taste test scores <it>within </it>hypothesised taster groups, is likely to be, or at least in part, due to physiological differentiation regulated by other genetic contributors. Results confirm relationships between genetic variation and bitter compound tasting ability in a large sample, and suggest that <it>TAS2R38 </it>variation may also be associated with intermediate tasting ability.</p>http://www.biomedcentral.com/1471-2156/8/51 |
| spellingShingle | Bartoshuk Linda M Ring Susan M Day Ian NM Heron Jon Timpson Nicholas J Horwood Jeremy Emmett Pauline Davey-Smith George Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children BMC Genetics |
| title | Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children |
| title_full | Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children |
| title_fullStr | Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children |
| title_full_unstemmed | Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children |
| title_short | Refining associations between <it>TAS2R38 </it>diplotypes and the 6-<it>n</it>-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children |
| title_sort | refining associations between it tas2r38 it diplotypes and the 6 it n it propylthiouracil prop taste test findings from the avon longitudinal study of parents and children |
| url | http://www.biomedcentral.com/1471-2156/8/51 |
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